Glikolipid 6-a-manoziltransferaza

Из Википедије, слободне енциклопедије
Glikolipid 6-a-manoziltransferaza
Identifikatori
EC broj 2.4.1.232
CAS broj 346003-17-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glikolipid 6-a-manoziltransferaza (EC 2.4.1.232, alfa-1,6-manoziltransferaza, GDP-manoza:oligosaharid 1,6-alfa-D-manoziltransferaza, GDP-manoza:glikolipid 1,6-alfa-D-manoziltransferaza, glikolipid 6-alfa-manoziltransferaza, GDP-manoza:oligosaharid 1,6-alfa-D-manoziltransferaza) je enzim sa sistematskim imenom GDP-manoza:oligosaharid 6-alfa-D-manoziltransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

Prenosi alfa-D-manozilni ostatak sa GDP-manoze na oligosaharid vezan za lipid, formira alfa-(1->6)-D-manozil-D-manoznu vezu

Za dejstvo ovog enzima je neophodan Mn2+. Kod Saccharomyces cerevisiae ovaj enzim katalizuje esencijalni korak elongacije spoljašnjeg lanca N-vezanih oligosaharida. Man8GlcNAc i Man9GlcNAc su jednako dobri supstrati.

Reference[уреди]

  1. ^ Romero, P.A. and Herscovics, A. (1989). „Glycoprotein biosynthesis in Saccharomyces cerevisiae. Characterization of α-1,6-mannosyltransferase which initiates outer chain formation“. J. Biol. Chem. 264: 1946-1950. PMID 2644248. 
  2. ^ Reason, A.J., Dell, A., Romero, P.A. and Herscovics, A. (1991). „Specificity of the mannosyltransferase which initiates outer chain formation in Saccharomyces cerevisiae“. Glycobiology 1: 387-391. PMID 1820199. 
  3. ^ Nakanishi-Shindo, Y., Nakayama, K., Tanaka, A., Toda, Y. and Jigami, Y. (1993). „Structure of the N-linked oligosaccharides that show the complete loss of α-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae“. J. Biol. Chem. 268: 26338-26345. PMID 8253757. 
  4. ^ Yamamoto, K., Okamoto, M., Yoko-o, T. and Jigami, Y. (2003). „Salt stress induces the expression of the Schizosaccharomyces pombe och1+, which encodes an initiation-specific α-1,6-mannosyltransferase for N-linked outer chain synthesis of cell wall mannoproteins“. Biosci. Biotechnol. Biochem. 67: 927-929. PMID 12784644. 
  5. ^ Cui, Z., Horecka, J. and Jigami, Y. (2002). „Cdc4 is involved in the transcriptional control of OCH1, a gene encoding α-1,6-mannosyltransferase in Saccharomyces cerevisiae“. Yeast 19: 69-77. PMID 11754484. 
  6. ^ Tsukahara, K., Watanabe, T., Yoko-o, T. and Chigami, Y. (2001). „Schizosaccharomyces pombe och1+ gene encoding α-1,6-mannosyltransferase and use of och1+ gene knockout fission yeast for production of glycoproteins with reduced glycosylation“. Jpn. Kokai Tokkyo Koho Koho: 11-11. 
  7. ^ Nakayama, K., Nakanishi-Shindo, Y., Tanaka, A., Haga-Toda, Y. and Jigami, Y. (1997). „Substrate specificity of α-1,6-mannosyltransferase that initiates N-linked mannose outer chain elongation in Saccharomyces cerevisiae“. FEBS Lett. 412: 547-550. PMID 9276464. 
  8. ^ Suzuki, A., Shibata, N., Suzuki, M., Saitoh, F., Takata, Y., Oshie, A., Oyamada, H., Kobayashi, H., Suzuki, S. and Okawa, Y. (1996). „Characterization of α-1,6-mannosyltransferase responsible for the synthesis of branched side chains in Candida albicans mannan“. Eur. J. Biochem. 240: 37-44. PMID 8797833. 
  9. ^ Yip, C.L., Welch, S.K., Klebl, F., Gilbert, T., Seidel, P., Grant, F., O'Hara, P.J. and MacKay, V.L. (1994). „Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins“. Proc. Natl. Acad. Sci. USA 91: 2723-2727. PMID 8146181. 

Literatura[уреди]

Spoljašnje vezе[уреди]