Glutation-disulfid reduktaza

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Glutation-disulfid reduktaza
Glutathione reductase.png
PDB prikaz baziran na 1GRE.
Identifikatori
EC broj 1.8.1.7
CAS broj 9001-48-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glutation-disulfid reduktaza (EC 1.8.1.7, glutationska reduktaza, glutationska reduktaza (NADPH), NADPH-glutationska reduktaza, GSH reduktaza, GSSG reduktaza, NADPH-GSSG reduktaza, glutationska S-reduktaza, NADPH:oksidovani-glutation oksidoreduktaza) je enzim sa sistematskim imenom glutation:NADP+ oksidoreduktaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 glutation + NADP+ \rightleftharpoons glutation disulfid + NADPH + H+

Ovaj enzim je dimerni flavoprotein (FAD). Njegova aktivnost je zavisna od redoks-aktivnog disulfida u svakom od aktivnih mesta.

Reference[уреди]

  1. Pai, E.F., Schirmer, R.H. and Schulz, G.E. (1978). „Structural studies on crystalline glutathione reductase from human erythrocytes“. In Singer, T.P. and Ondarza, R.N.. Mechanisms of Oxidizing Enzymes. New York: Mechanisms of Oxidizing Enzymes. стр. 17-22. 
  2. Pigiet, V.P. and Conley, R.R. (1977). „Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography“. J. Biol. Chem. 252: 6367-6372. PMID 330529. 
  3. Racker, E. (1955). „Glutathione reductase from bakers' yeast and beef liver“. J. Biol. Chem. 217: 855-865. PMID 13271446. 
  4. van Heyningen, R. and Pirie, A. (1953). „Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens“. Biochem. J. 53: 436-444. PMID 13032091. 
  5. Worthington, D.J. and Rosemeyer, M.A. (1976). „Glutathione reductase from human erythrocytes. Catalytic properties and aggregation“. Eur. J. Biochem. 67: 231-238. PMID 9277. 
  6. Böhmé, C.C., Arscott, L.D., Becker, K., Schirmer, R.H. and Williams, C.H., Jr. (2000). „Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme“. J. Biol. Chem. 275: 37317-37323. PMID 10969088. 
  7. Libreros-Minotta, C.A., Pardo, J.P., Mendoza-Hernandez, G. and Rendon, J.L. (1992). „Purification and characterization of glutathione reductase from Rhodospirillum rubrum“. Arch. Biochem. Biophys. 298: 247-253. PMID 1524433. 

Literatura[уреди]

Spoljašnje veze[уреди]