Glutation-disulfid reduktaza

Из Википедије, слободне енциклопедије
Glutation-disulfid reduktaza
Glutathione reductase.png
PDB prikaz baziran na 1GRE.
Identifikatori
EC broj 1.8.1.7
CAS broj 9001-48-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glutation-disulfid reduktaza (EC 1.8.1.7, glutationska reduktaza, glutationska reduktaza (NADPH), NADPH-glutationska reduktaza, GSH reduktaza, GSSG reduktaza, NADPH-GSSG reduktaza, glutationska S-reduktaza, NADPH:oksidovani-glutation oksidoreduktaza) je enzim sa sistematskim imenom glutation:NADP+ oksidoreduktaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 glutation + NADP+ \rightleftharpoons glutation disulfid + NADPH + H+

Ovaj enzim je dimerni flavoprotein (FAD). Njegova aktivnost je zavisna od redoks-aktivnog disulfida u svakom od aktivnih mesta.

Reference[уреди]

  1. ^ Pai, E.F., Schirmer, R.H. and Schulz, G.E. (1978). „Structural studies on crystalline glutathione reductase from human erythrocytes“. In Singer, T.P. and Ondarza, R.N.. Mechanisms of Oxidizing Enzymes. New York: Mechanisms of Oxidizing Enzymes. стр. 17-22. 
  2. ^ Pigiet, V.P. and Conley, R.R. (1977). „Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography“. J. Biol. Chem. 252: 6367-6372. PMID 330529. 
  3. ^ Racker, E. (1955). „Glutathione reductase from bakers' yeast and beef liver“. J. Biol. Chem. 217: 855-865. PMID 13271446. 
  4. ^ van Heyningen, R. and Pirie, A. (1953). „Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens“. Biochem. J. 53: 436-444. PMID 13032091. 
  5. ^ Worthington, D.J. and Rosemeyer, M.A. (1976). „Glutathione reductase from human erythrocytes. Catalytic properties and aggregation“. Eur. J. Biochem. 67: 231-238. PMID 9277. 
  6. ^ Böhmé, C.C., Arscott, L.D., Becker, K., Schirmer, R.H. and Williams, C.H., Jr. (2000). „Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme“. J. Biol. Chem. 275: 37317-37323. PMID 10969088. 
  7. ^ Libreros-Minotta, C.A., Pardo, J.P., Mendoza-Hernandez, G. and Rendon, J.L. (1992). „Purification and characterization of glutathione reductase from Rhodospirillum rubrum“. Arch. Biochem. Biophys. 298: 247-253. PMID 1524433. 

Literatura[уреди]

Spoljašnje veze[уреди]