Granzim B

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Granzim B
Identifikatori
EC broj 3.4.21.79
CAS broj 143180-74-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Granzim B (EC 3.4.21.79, CTLA1, CCPII, citotoksna ćelijska proteinaza-1, granzim G, granzim H, CCP1 proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno odvajanje: -Asp- >> -Asn- > -Met-, -Ser-

Ovaj enzim je prisutan u citotoksičnim T limfocitnim granulama.

Reference[уреди]

  1. ^ Schmid, J. and Weissmann, C. (1987). „Induction of mRNA for a serine protease and a β-thromboglobulin-like protein in mitogen-stimulated human leukocytes“. J. Immunol. 139: 250-256. PMID 2953813. 
  2. ^ Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C. (1991). „Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins“. Biochemistry 30: 2217-2227. PMID 1998680. 
  3. ^ Poe, M., Blake, J.T., Boulton, D.A., Gammon, M., Sigal, N.H., Wu, J.K. and Zweerink, H.J. (1991). „Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity“. J. Biol. Chem. 266: 98-103. PMID 1985927. 

Literatura[уреди]

Spoljašnje vezе[уреди]