Hinoprotein glukoza dehidrogenaza

Из Википедије, слободне енциклопедије
Hinoprotein glukoza dehidrogenaza
Identifikatori
EC broj 1.1.5.2
CAS broj 81669-60-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Hinoprotein glukoza dehidrogenaza (EC 1.1.5.2, membranska glukozna dehidrogenaza, mGDH, glukozna dehidrogenaza (PQQ-zavisna), glukozna dehidrogenaza (pirolohinolin-hinon), hinoproteinska D-glukozna dehidrogenaza) je enzim sa sistematskim imenom D-glukoza:ubihinon oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-glukoza + ubihinon \rightleftharpoons D-glukono-1,5-lakton + ubihinol

Ovaj integralni membranski protein sadrži PQQ kao prostetičku grupu. On takođe sadrži vezan ubihinon i Mg2+ ili Ca2+. Elektronski akceptor je membranski ubihinon.

Reference[уреди]

  1. ^ Yamada, M., Sumi, K., Matsushita, K., Adachi, O. and Yamada, Y. (1993). „Topological analysis of quinoprotein glucose-dehydrogenase in Escherichia coli and its ubiquinone-binding site“. J. Biol. Chem. 268: 12812-12817. PMID 8509415. 
  2. ^ Dewanti, A.R. and Duine, J.A. (1998). „Reconstitution of membrane-integrated quinoprotein glucose dehydrogenase apoenzyme with PQQ and the holoenzyme's mechanism of action“. Biochemistry 37: 6810-6818. PMID 9578566. 
  3. ^ Duine, J.A., Frank, J. and Van Zeeland, J.K. (1979). „Glucose dehydrogenase from Acinetobacter calcoaceticus: a 'quinoprotein'“. FEBS Lett. 108: 443-446. PMID 520586. 
  4. ^ Ameyama, M., Matsushita, K., Ohno, Y., Shinagawa, E. and Adachi, O. (1981). „Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria“. FEBS Lett. 130: 179-183. PMID 6793395. 
  5. ^ Cozier, G.E. and Anthony, C. (1995). „Structure of the quinoprotein glucose dehydrogenase of Escherichia coli modelled on that of methanol dehydrogenase from Methylobacterium extorquens“. Biochem. J. 312: 679-685. PMID 8554505. 
  6. ^ Cozier, G.E., Salleh, R.A. and Anthony, C. (1999). „Characterization of the membrane quinoprotein glucose dehydrogenase from Escherichia coli and characterization of a site-directed mutant in which histidine-262 has been changed to tyrosine“. Biochem. J. 340: 639-647. PMID 10359647. 
  7. ^ Elias, M.D., Tanaka, M., Sakai, M., Toyama, H., Matsushita, K., Adachi, O. and Yamada, M. (2001). „C-terminal periplasmic domain of Escherichia coli quinoprotein glucose dehydrogenase transfers electrons to ubiquinone“. J. Biol. Chem. 276: 48356-48361. PMID 11604400. 
  8. ^ James, P.L. and Anthony, C. (2003). „The metal ion in the active site of the membrane glucose dehydrogenase of Escherichia coli“. Biochim. Biophys. Acta 1647: 200-205. PMID 12686133. 
  9. ^ Elias, M.D., Nakamura, S., Migita, C.T., Miyoshi, H., Toyama, H., Matsushita, K., Adachi, O. and Yamada, M. (2004). „Occurrence of a bound ubiquinone and its function in Escherichia coli membrane-bound quinoprotein glucose dehydrogenase“. J. Biol. Chem. 279: 3078-3083. PMID 14612441. 
  10. ^ Mustafa, G., Ishikawa, Y., Kobayashi, K., Migita, C.T., Elias, M.D., Nakamura, S., Tagawa, S. and Yamada, M. (2008). „Amino acid residues interacting with both the bound quinone and coenzyme, pyrroloquinoline quinone, in Escherichia coli membrane-bound glucose dehydrogenase“. J. Biol. Chem. 283: 22215-22221. PMID 18550551. 

Literatura[уреди]

Spoljašnje veze[уреди]