Histonska deacetilaza

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Histonska deacetilaza
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Identifikatori
EC broj 3.5.1.98
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Histonska deacetilaza (EC 3.5.1.98, HDAC) je enzim sa sistematskim imenom histon amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza N6-acetil-lizinskog ostatka histona čime se formira deacetilisani histon

Ova klasa enzima uklanja acetil grupe sa N6-acetil-lizinskih ostataka na histonu.

Reference[уреди]

  1. ^ Krieger, D.E., Levine, R., Merrifield, R.B., Vidali, G. and Allfrey, V.G. (1974). „Chemical studies of histone acetylation. Substrate specificity of a histone deacetylase from calf thymus nuclei“. J. Biol. Chem. 249: 332-334. PMID 4855628. 
  2. ^ Sanchez del Pino, M.M., Lopez-Rodas, G., Sendra, R. and Tordera, V. (1994). „Properties of the yeast nuclear histone deacetylase“. Biochem. J. 303: 723-729. PMID 7980438. 
  3. ^ Ouaissi, M. and Ouaissi, A. (2006). „Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases“. J. Biomed. Biotechnol. 2006: 13474-13474. PMID 16883049. 
  4. ^ Song, Y.M., Kim, Y.S., Kim, D., Lee, D.S. and Kwon, H.J. (2007). „Cloning, expression, and biochemical characterization of a new histone deacetylase-like protein from Thermus caldophilus GK24“. Biochem. Biophys. Res. Commun. 361: 55-61. PMID 17632079. 
  5. ^ Finnin, M.S., Donigian, J.R., Cohen, A., Richon, V.M., Rifkind, R.A., Marks, P.A., Breslow, R. and Pavletich, N.P. (1999). „Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors“. Nature 401: 188-193. PMID 10490031. 
  6. ^ Phiel, C.J., Zhang, F., Huang, E.Y., Guenther, M.G., Lazar, M.A. and Klein, P.S. (2001). „Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen“. J. Biol. Chem. 276: 36734-36741. PMID 11473107. 
  7. ^ de Ruijter, A.J., van Gennip, A.H., Caron, H.N., Kemp, S. and van Kuilenburg, A.B. (2003). „Histone deacetylases (HDACs): characterization of the classical HDAC family“. Biochem. J. 370: 737-749. PMID 12429021. 

Literatura[уреди]

Spoljašnje veze[уреди]