Hormon-senzitivna lipaza

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Hormon-senzitivna lipaza
Identifikatori
EC broj 3.1.1.79
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Hormon-senzitivna lipaza (EC 3.1.1.79, HSL) je enzim sa sistematskim imenom diacilglicerol acilhidrolaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) diacilglicerol + H2O \rightleftharpoons monoacilglicerol + karboksilat
(2) triacilglicerol + H2O \rightleftharpoons diacilglicerol + karboksilat
(3) monoacilglicerol + H2O \rightleftharpoons glicerol + karboksilat

Ovaj enzim je serinska hidrolaza.

Reference[уреди]

  1. ^ Holm, C., Osterlund, T., Laurell, H. and Contreras, J.A. (2000). „Molecular mechanisms regulating hormone-sensitive lipase and lipolysis“. Annu. Rev. Nutr. 20: 365-393. PMID 10940339. 
  2. ^ Fredrikson, G., Stralfors, P., Nilsson, N.O. and Belfrage, P. (1981). „Hormone-sensitive lipase of rat adipose tissue. Purification and some properties“. J. Biol. Chem. 256: 6311-6320. PMID 7240206. 
  3. ^ Vaughan, M., Berger, J.E. and Steinberg, D. (1964). „Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue“. J. Biol. Chem. 239: 401-409. PMID 14169138. 
  4. ^ Østerlund, T., Danielsson, B., Degerman, E., Contreras, J.A., Edgren, G., Davis, R.C., Schotz, M.C. and Holm, C. (1996). „Domain-structure analysis of recombinant rat hormone-sensitive lipase“. Biochem. J. 319 ( Pt 2): 411-420. PMID 8912675. 
  5. ^ Lee, F.T., Adams, J.B., Garton, A.J. and Yeaman, S.J. (1988). „Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones“. Biochim. Biophys. Acta 963: 258-264. PMID 3196730. 
  6. ^ Wei, S., Lai, K., Patel, S., Piantedosi, R., Shen, H., Colantuoni, V., Kraemer, F.B. and Blaner, W.S. (1977). „Retinyl ester hydrolysis and retinol efflux from BFC-1β adipocytes“. J. Biol. Chem. 272: 14159-14165. PMID 9162045. 
  7. ^ Tsujita, T., Ninomiya, H. and Okuda, H. (1989). „p-Nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue“. J. Lipid Res. 30: 997-1004. PMID 2794798. 
  8. ^ Yeaman, S.J. (2004). „Hormone-sensitive lipase - new roles for an old enzyme“. Biochem. J. 379: 11-22. PMID 14725507. 

Literatura[уреди]

Spoljašnje vezе[уреди]