Inozitol-fosfat fosfataza

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Inozitol-fosfat fosfataza
Identifikatori
EC broj 3.1.3.25
CAS broj 37184-63-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Inozitol-fosfat fosfataza (EC 3.1.3.25, mio-inozitol-1(ili 4)-monofosfataza, inozitol 1-fosfataza, L-mio-inozitol-1-fosfat fosfataza, mio-inozitol 1-fosfataza, inozitolna fosfataza, inozitol monofosfatna fosfataza, inozitol-1(ili 4)-monofosfataza, mio-inozitol-1(ili 4)-fosfatna fosfohidrolaza, mio-inozitolna monofosfataza, mio-inozitol-1-fosfataza) je enzim sa sistematskim imenom mio-inozitol-fosfat fosfohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

mio-inozitol fosfat + H2O \rightleftharpoons mio-inozitol + fosfat

Ovaj enzim deluje na pet od šest mogućih izomera mio-inozitol fosfata, na sve sem mio-inozitol 2-fosfata.

Reference[уреди]

  1. ^ Eisenberg, F., Jr. (1967). „D-Myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis“. J. Biol. Chem. 242: 1375-1382. PMID 4290245. 
  2. ^ Gee, N.S., Ragan, C.I., Watling, K.J., Aspley, S., Jackson, R.G., Reid, G.G., Gani, D. and Shute, J.K. (1988). „The purification and properties of myo-inositol monophosphatase from bovine brain“. Biochem. J. 249: 883-889. PMID 2833231. 
  3. ^ Hallcher, L.M. and Sherman, W.R. (1980). „The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain“. J. Biol. Chem. 255: 10896-10901. PMID 6253491. 
  4. ^ Yoshikawa, T., Turner, G., Esterling, L.E., Sanders, A.R. and Detera-Wadleigh, S.D. (1997). „A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder“. Mol. Psychiatry 2: 393-397. PMID 9322233. 
  5. ^ Woscholski, R. and Parker, P.J. (2000). „Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates“. In Cockcroft, S.. Biology of Phosphoinositides. Oxford: Biology of Phosphoinositides. стр. 320-338. 
  6. ^ Ackermann, K.E., Gish, B.G., Honchar, M.P. and Sherman, W.R. (1987). „Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism“. Biochem. J. 242: 517-524. PMID 3036092. 

Литература[уреди]

  • Woscholski, R. and Parker, P.J. (2000). „Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates“. In Cockcroft, S.. Biology of Phosphoinositides. Oxford: Biology of Phosphoinositides. стр. 320-338. 

Spoljašnje veze[уреди]