Kalikrein
Kalikreini su podgrupa serinskih proteaza, enzima koji imaju sposobnost razlaganja peptidnih veza u proteinima. Kod ljudi, kalikrein plazme[1][2][3][4][5] (KLKB1) nema poznatih homologa, dok tkivne kalikreinu srodne peptidaze (KLKs) kodiraju familiju od petnaest blisko srodnih serinskih proteaza. Ti geni su locirani na hromozomu 19q13, i formiraju najveći kluster susednih proteaza u ljudskom genomu. Kalikreini su odgovorni za koordinaciju raznih fizioloških funkcija uključujući krvni pritisak, utečnjavanje semena i deskvamaciju kože.
Reference[уреди | уреди извор]
- ^ Heimark, R.L. & Davie, E.W. (1981). „Bovine and human plasma prekallikrein”. Methods Enzymol. 80: 157—172. PMID 6918767.
- ^ McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. (1981). „Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates”. Biochemistry. 20: 7196—7206. PMID 6976185.
- ^ Silverberg, M. & Kaplan, A.P. (1988). „Prekallikrein”. Methods Enzymol. 163: 85—95. PMID 3237096.
- ^ Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. (1989). „The cDNA structure of rat plasma kallikrein”. DNA. 8: 563—574. PMID 2598771.
- ^ Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. (1989). „Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein”. Chem. Pharm. Bull. 37: 3108—3111. PMID 2534361.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Vidi još[уреди | уреди извор]
- Kalikrein plazme, enzim
- Kalikrein renalnog tkiva, enzim
Spoljašnje veze[уреди | уреди извор]
- MEROPS onlajn baza podataka o peptidazama i njihovim inhibitorima: S01.212 Архивирано на сајту Wayback Machine (27. мај 2020)
- Kallikreins на US National Library of Medicine Medical Subject Headings (MeSH)
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