Kaspaza-8

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Kaspaza-8
Identifikatori
EC broj 3.4.22.61
CAS broj 179241-78-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Kaspaza-8 (EC 3.4.22.61, FLICE, FADD-sličan ICE, MACH, MORT1-asocirani CED-3 homolog, Mch5, sisarski Ced-3 homolog 5, CASP-8, ICE-slična apoptotička proteaza 5, FADD-homologna ICE/CED-3-slična proteaza, apoptotička cisteinska proteaza, apoptotička proteaza Mch-5, CAP4) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence (Leu/Asp/Val)-Glu-Thr-Asp-(Gly/Ser/Ala)

Kaspaza-8 je efektor/izvršilac kaspaze, kao što su i kaspaza-2 (EC 3.4.22.55), kaspaza-9 (EC 3.4.22.62) i kaspaza-10 (EC 3.4.22.63).

Reference[уреди]

  1. Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases“. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820. 
  2. Boldin, M.P., Goncharov, T.M., Goltsev, Y.V. and Wallach, D. (1996). „Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death“. Cell 85: 803-815. PMID 8681376. 
  3. Muzio, M., Chinnaiyan, A.M., Kischkel, F.C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J.D., Zhang, M., Gentz, R., Mann, M., Krammer, P.H., Peter, M.E. and Dixit, V.M. (1996). „FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex“. Cell 85: 817-827. PMID 8681377. 
  4. Salvesen, G.S. and Boatright, K.M. (2004). „Caspase-8“. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. стр. 1293-1296. 
  5. Fischer, U., Stroh, C. and Schulze-Osthoff, K. (2006). „Unique and overlapping substrate specificities of caspase-8 and caspase-10“. Oncogene 25: 152-159. PMID 16186808. 
  6. Blanchard, H., Donepudi, M., Tschopp, M., Kodandapani, L., Wu, J.C. and Grütter, M.G. (2000). „Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex“. J. Mol. Biol. 302: 9-16. PMID 10964557. 
  7. Boatright, K.M., Deis, C., Denault, J.B., Sutherlin, D.P. and Salvesen, G.S. (2004). „Activation of caspases-8 and -10 by FLIPL“. Biochem. J. 382: 651-657. PMID 15209560. 

Литература[уреди]

  • Salvesen, G.S. and Boatright, K.M. (2004). „Caspase-8“. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. стр. 1293-1296. 

Spoljašnje veze[уреди]