Kortikotropinu-sličan intermedijarni peptid

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Kortikotropinu-sličan intermedijarni peptid
IUPAC ime
Identifikacija
CAS registarski broj 53917-42-3
PubChem[1][2] 16133227
ChemSpider[3] 14195066
Svojstva
Molekulska formula C112H165N27O36
Molarna masa 2465,668 g/mol



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Kortikotropin-sličan intermedijarni peptid[4] (CLIP, adrenokortikotropni hormonski fragment 18-39, ACTH (18-39)) je prirodni endogeni neuropeptid sa dokozapeptidnom strukturom i aminokiselinskom sekvencom Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP nastaje kao proizvod proteolitičkog razlaganja adrenokortikotropnog hormona (ACTH),[5][6] koji je produkt razlaganja proopiomelanokortina (POMC).[7] Mada ne izgleda da ima posebno važnu ulogu u telu,[8] on ima izvesna biološka dejstva,[9][10] posebno u neurološkim sistemima.[11][12][13][14][15]

Vidi još[уреди]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Silvana Andrić, Tatjana Kostić, Nebojša Andrić, Sonja Zorić (2006). Uporedna fiziologija životinja. Novi Sad: WUS Austria, Daniel Print. ISBN 86-7031-074-0. 
  5. ^ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). „Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia“. The Journal of Biological Chemistry 254 (23): 11903–6. PMID 227883. 
  6. ^ Fricker, Lloyd D. (24. 7. 1991.). Peptide biosynthesis and processing. CRC Press. стр. 78. ISBN 978-0-8493-8852-1 Приступљено 25 November 2011. 
  7. ^ Norman, Anthony W.; Litwack, Gerald (26. 9. 1997.). Hormones. Academic Press. стр. 12. ISBN 978-0-12-521441-4 Приступљено 25 November 2011. 
  8. ^ Larry Rex Engelking (1. 6. 2002.). Review of veterinary physiology. Teton NewMedia. стр. 411. ISBN 978-1-893441-69-9 Приступљено 25 November 2011. 
  9. ^ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). „Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules“. The Journal of Clinical Investigation 74 (5): 1886–9. DOI:10.1172/JCI111608. PMC 425369. PMID 6209301. 
  10. ^ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). „Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain“. Brain Research Bulletin 26 (1): 99–111. PMID 1849784. 
  11. ^ Inoué, Shojiro; Inoué, Shojiro (1989). Biology of sleep substances. CRC Press. стр. 136. ISBN 978-0-8493-4822-8 Приступљено 25 November 2011. 
  12. ^ Chastrette N, Cespuglio R, Jouvet M (February 1990). „Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives“. Neuropeptides 15 (2): 61–74. PMID 1981927. 
  13. ^ Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). „Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes“. Neuropeptides 15 (2): 75–88. PMID 1964203. 
  14. ^ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). „Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain“. Bulletin of Experimental Biology and Medicine 147 (3): 319–22. PMID 19529852. 
  15. ^ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). „Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)“]. Peptides 14 (6): 1221–4. PMID 8134304. 

Literatura[уреди]

Spoljašnje veze[уреди]