Legumain

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Legumain
Identifikatori
EC broj 3.4.22.34
CAS broj 149371-18-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Legumain (EC 3.4.22.34, asparaginska endopeptidaza, citvak, proteinaza B, hemoglobinaza, PRSC1 genski produkt (Homo sapiens), vicilinska peptidohidrolaza, endopeptidaza pasulja, vicilinska peptidohidrolaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina i malih molekulskih supstrata na -Asn-Xaa- vezama

Ovaj enzim je prisutan u mahunama metilja Schistosoma mansoni, i u lizozomima sisara.

Reference[уреди]

  1. ^ Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase“. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 746-749. 
  2. ^ Dalton, J.P. and Brindley, P.J. (1998). „Schistosome legumain“. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 749-754. 
  3. ^ Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. (1998). „Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases“. FEBS Lett. 441: 361-365. PMID 9891971. 

Литература[уреди]

  • Dalton, J.P. and Brindley, P.J. (1998). „Schistosome legumain“. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 749-754. 
  • Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase“. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 746-749. 

Spoljašnje veze[уреди]