Levonantradol

Из Википедије, слободне енциклопедије
Levonantradol
(IUPAC) ime
[(6S,6aR,9R,10aR)- 9-hidroksi- 6-metil- 3-[(2R)-5-fenilpentan- 2-il]oksi- 5,6,6a,7,8,9,10,10a-oktahidrofenantridin- 1-il] acetat
Klinički podaci
Identifikatori
CAS broj 71048-87-8
ATC kod nije dodeljen
PubChem[1][2] 5361881
ChemSpider[3] 4514867
UNII 03S640ADSK YesY
Hemijski podaci
Formula C27H35NO4 
Mol. masa 437,571 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Levonantradol (CP 50,556-1) je sintetički kanabinoidni analog dronabinola (Marinola). Ovaj lek je razvila kompanija Pfizer tokom 1980-tih. On je oko 30x puta potentniji od THC, i manifestuje antiemetske i analgetske efekte putem aktivacije CB1 i CB2 kanabinoidnih receptora.[4] Levonantradol trenutno nije u upotrebi jer su dronabinol i nabilon primenljivi na veći broj oboljenja. On nalazi široku primenu u istraživanju potencijalne terapeutske primene kanabinoida.[5][6][7]

Vidi još[уреди]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Little PJ, et al. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. Journal of Pharmacology and Experimental Therapeutics 1988; 247:1046–1051.
  5. ^ Tramer MR, et al. Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. British Medical Journal 2001 Jul 7;323(7303):16-21.
  6. ^ Campbell FA, et al. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. British Medical Journal. 2001 Jul 7;323(7303):13-6.
  7. ^ Ben Amar M. Cannabinoids in medicine: A review of their therapeutic potential. Journal of Ethnopharmacology. 2006 Apr 21;105(1-2):1-25.

Literatura[уреди]

Spoljašnje veze[уреди]