Mijeloperoksidaza

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Mijeloperoksidaza
Myeloperoxidase.png
Identifikatori
EC broj 1.11.2.2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Mijeloperoksidaza (EC 1.11.2.2, MPO, verdoperoksidaza) je enzim sa sistematskim imenom hlorid:vodonik-peroksid oksidoreduktaza (formira hipohlorit).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Cl- + H2O2 + H+ \rightleftharpoons HClO + H2O

Ovaj enzim sadrži kalcijum i kovalentno vezani hem. On je presutan u fagozomima neutrofila i monocita, gde je formirani hipohlorit veoma baktericidan.

Reference[уреди]

  1. ^ Agner, K. (1943). „Myeloperoxidase“. Adv. Enzymol. 3: 137-148. 
  2. ^ Harrison, J.E. and Schultz, J. (1976). „Studies on the chlorinating activity of myeloperoxidase“. J. Biol. Chem. 251: 1371-1374. PMID 176150. 
  3. ^ Furtmuller, P.G., Burner, U. and Obinger, C. (1998). „Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate“. Biochemistry 37: 17923-17930. PMID 9922160. 
  4. ^ Tuynman, A., Spelberg, J.L., Kooter, I.M., Schoemaker, H.E. and Wever, R. (2000). „Enantioselective epoxidation and carbon-carbon bond cleavage catalyzed by Coprinus cinereus peroxidase and myeloperoxidase“. J. Biol. Chem. 275: 3025-3030. PMID 10652281. 
  5. ^ Klebanoff, S.J. (2005). „Myeloperoxidase: friend and foe“. J. Leukoc. Biol. 77: 598-625. PMID 15689384. 
  6. ^ Fiedler, T.J., Davey, C.A. and Fenna, R.E. (2000). „X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 Å resolution“. J. Biol. Chem. 275: 11964-11971. PMID 10766826. 
  7. ^ Gaut, J.P., Yeh, G.C., Tran, H.D., Byun, J., Henderson, J.P., Richter, G.M., Brennan, M.L., Lusis, A.J., Belaaouaj, A., Hotchkiss, R.S. and Heinecke, J.W. (2001). „Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis“. Proc. Natl. Acad. Sci. USA 98: 11961-11966. PMID 11593004. 

Literatura[уреди]

Spoljašnje veze[уреди]