Mijeloperoksidaza
Из Википедије, слободне енциклопедије
| Mijeloperoksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 1.11.2.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | structures | ||||||||
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Mijeloperoksidaza (EC 1.11.2.2, MPO, verdoperoksidaza) je enzim sa sistematskim imenom hlorid:vodonik-peroksid oksidoreduktaza (formira hipohlorit).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Cl- + H2O2 + H+
HClO + H2O
HClO + H2OOvaj enzim sadrži kalcijum i kovalentno vezani hem. On je presutan u fagozomima neutrofila i monocita, gde je formirani hipohlorit veoma baktericidan.
Reference [уреди]
- ^ Agner, K. (1943). „Myeloperoxidase“. Adv. Enzymol. 3: 137-148.
- ^ Harrison, J.E. and Schultz, J. (1976). „Studies on the chlorinating activity of myeloperoxidase“. J. Biol. Chem. 251: 1371-1374. PMID 176150.
- ^ Furtmuller, P.G., Burner, U. and Obinger, C. (1998). „Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate“. Biochemistry 37: 17923-17930. PMID 9922160.
- ^ Tuynman, A., Spelberg, J.L., Kooter, I.M., Schoemaker, H.E. and Wever, R. (2000). „Enantioselective epoxidation and carbon-carbon bond cleavage catalyzed by Coprinus cinereus peroxidase and myeloperoxidase“. J. Biol. Chem. 275: 3025-3030. PMID 10652281.
- ^ Klebanoff, S.J. (2005). „Myeloperoxidase: friend and foe“. J. Leukoc. Biol. 77: 598-625. PMID 15689384.
- ^ Fiedler, T.J., Davey, C.A. and Fenna, R.E. (2000). „X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 Å resolution“. J. Biol. Chem. 275: 11964-11971. PMID 10766826.
- ^ Gaut, J.P., Yeh, G.C., Tran, H.D., Byun, J., Henderson, J.P., Richter, G.M., Brennan, M.L., Lusis, A.J., Belaaouaj, A., Hotchkiss, R.S. and Heinecke, J.W. (2001). „Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis“. Proc. Natl. Acad. Sci. USA 98: 11961-11966. PMID 11593004.
