Mikotiol-zavisna formaldehid dehidrogenaza
| Mikotiol-zavisna formaldehid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.66 | ||||||||
| CAS broj | 192140-85-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Mikotiol-zavisna formaldehid dehidrogenaza (EC 1.2.1.66, NAD/factor-zavisna formaldehidna dehidrogenaza) je enzim sa sistematskim imenom formaldehid:NAD+ oksidoreduktaza (mikotiol-formilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- formaldehid + mikotiol + NAD+ S-formilmikotiol + NADH + 2 H+
Formirani S-formilmikotiol se hidrolizuje do mikotiola i formata.
Reference[уреди | уреди извор]
- ^ Misset-Smits, M., Van Ophem, P.W., Sakuda, S. and Duine, J.A. (1997). „Mycothiol, 1-O-(2′-[N-acetyl-L-cysteinyl]amido-2′-deoxy-α-D-glucopyranosyl)-D-myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase”. FEBS Lett. 409: 221—222. PMID 9202149.
- ^ Norin, A., Van Ophem, P.W., Piersma, S.R., Person, B., Duine, J.A. and Jornvall, H. (1997). „Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaryotic alcohol dehydrogenase's - primary structure, conformational modelling and functional correlations”. Eur. J. Biochem. 248: 282—289. PMID 9346279.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Mycothiol-dependent+formaldehyde+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
