Monofenol monooksigenaza

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Monofenol monooksigenaza
Identifikatori
EC broj 1.14.18.1
CAS broj 2594228
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Monofenol monooksigenaza (EC 1.14.18.1, fenolaza, monofenol oksidaza, krezolaza, monofenolaza, tirozin-dopa oksidaza, monofenolna monooksidaza, monofenol dihidroksifenilalanin:kiseonik oksidoreduktaza, N-acetil-6-hidroksitriptofan oksidaza, monofenol, dihidroksi-L-fenilalanin kiseonik oksidoreduktaza, o-difenol:O2 oksidoreduktaza, fenol oksidaza) je enzim sa sistematskim imenom L-tirozin,L-dopa:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10][11][12] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) L-tirozin + O2 \rightleftharpoons dopahinon + H2O (sveukupna reakcija)
(1a) L-tirozin + 1/2 O2 \rightleftharpoons L-dopa
(1b) L-dopa + 1/2 O2 \rightleftharpoons dopahinon +H2O
(2) 2 L-dopa + O2 \rightleftharpoons 2 dopahinon + 2H2O

Ovaj enzim je tip III bakarni protein prisutan u širokom varijetetu bakterija, gljiva, biljki, insekata, rakova i sisara. On učestvuje u sintezi betalaina i melanina.

Reference[уреди]

  1. ^ Dawson, C.R. and Tarpley, W.B. (1951). „The copper oxidases“. In Sumner, J.B. and Myrbäck, K.. The Enzymes. 2 (1st ed.). New York: Academic Press. стр. 454-498. 
  2. ^ Patil, S.S. and Zucker, M. (1965). „Potato phenolases. Purification and properties“. J. Biol. Chem. 240: 3938-3943. PMID 5842066. 
  3. ^ Pomerantz, S.H. (1963). „Separation, purification, and properties of two tyrosinases from hamster melanoma“. J. Biol. Chem. 238: 2351-2357. PMID 13972077. 
  4. ^ Pomerantz, S.H. (1963). „Separation, purification, and properties of two tyrosinases from hamster melanoma“. J. Biol. Chem. 238: 2351-2357. PMID 13972077. 
  5. ^ Robb, D.A. (1984). „`Tyrosinase“. In Lontie, R.. Copper Proteins and Copper Enzymes. 2. Boca Raton, FL: CRC Press. стр. 207-240. 
  6. ^ Robb, D.A. (1984). „`Tyrosinase“. In Lontie, R.. Copper Proteins and Copper Enzymes. 2. Boca Raton, FL: CRC Press. стр. 207-240. 
  7. ^ Sanchez-Ferrer, A., Rodriguez-Lopez, J.N., Garcia-Canovas, F. and Garcia-Carmona, F. (1995). „Tyrosinase: a comprehensive review of its mechanism“. Biochim. Biophys. Acta 1247: 1-11. PMID 7873577. 
  8. ^ Sanchez-Ferrer, A., Rodriguez-Lopez, J.N., Garcia-Canovas, F. and Garcia-Carmona, F. (1995). „Tyrosinase: a comprehensive review of its mechanism“. Biochim. Biophys. Acta 1247: 1-11. PMID 7873577. 
  9. ^ Steiner, U., Schliemann, W. and Strack, D. (1996). „Assay for tyrosine hydroxylation activity of tyrosinase from betalain-forming plants and cell cultures“. Anal. Biochem. 238: 72-75. PMID 8660589. 
  10. ^ Steiner, U., Schliemann, W. and Strack, D. (1996). „Assay for tyrosine hydroxylation activity of tyrosinase from betalain-forming plants and cell cultures“. Anal. Biochem. 238: 72-75. PMID 8660589. 
  11. ^ Rolff, M., Schottenheim, J., Decker, H. and Tuczek, F. (2011). „Copper-O2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme“. Chem Soc Rev 40: 4077-4098. PMID 21416076. 
  12. ^ Rolff, M., Schottenheim, J., Decker, H. and Tuczek, F. (2011). „Copper-O2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme“. Chem Soc Rev 40: 4077-4098. PMID 21416076. 

Литература[уреди]

  • Robb, D.A. (1984). „`Tyrosinase“. In Lontie, R.. Copper Proteins and Copper Enzymes. 2. Boca Raton, FL: CRC Press. стр. 207-240. 
  • Robb, D.A. (1984). „`Tyrosinase“. In Lontie, R.. Copper Proteins and Copper Enzymes. 2. Boca Raton, FL: CRC Press. стр. 207-240. 
  • Dawson, C.R. and Tarpley, W.B. (1951). „The copper oxidases“. In Sumner, J.B. and Myrbäck, K.. The Enzymes. 2 (1st ed.). New York: Academic Press. стр. 454-498. 

Spoljašnje veze[уреди]