Nespecifična monooksigenaza

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Nespecifična monooksigenaza
EC broj
CAS broj 9038-14-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Nespecifična monooksigenaza (EC, microsomal monooksigenaza, ksenobiotik monooksigenaza, aril-4-monooksigenaza, aril hidrokarbon hidroksilaza, microsomal P-450, flavoprotein-vezani monooksigenaza, flavoprotein monooksigenaza) je enzim sa sistematskim imenom supstrat,redukovani-flavoprotein:kiseonik oksidoreduktaza (RH-hidroksilacija or -epoksidacija).[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Ovaj enzim katalizuje sledeću hemijsku reakciju

RH + redukovani flavoprotein + O2 \rightleftharpoons ROH + oksidovani flavoprotein + H2O

Nespecifična monooksigenaza je grupa hem-tiolatnih proteina (P-450), koji deluju na širok opseg supstrata uključujući mnoge ksenobiotike, steroide, masne kiseline, vitamine i prostaglandine.


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