Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza

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Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza
EC broj
CAS broj 37277-76-2
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza (EC, nikotinat mononukleotid-dimetilbenzimidazolna fosforiboziltransferaza, nikotinat ribonukleotid:benzimidazol (adenin) fosforiboziltransferaza, nikotinat-nukleotid:dimetilbenzimidazol fosfo-D-riboziltransferaza, CobT, nikotinat mononukleotid (NaMN):5,6-dimetilbenzimidazol fosforiboziltransferaza) je enzim sa sistematskim imenom nikotinat-nukleotid:5,6-dimetilbenzimidazol fosfo-D-riboziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

beta-nikotinat D-ribonukleotid + 5,6-dimetilbenzimidazol \rightleftharpoons nikotinat+ alfa-ribazole 5'-fosfat

Ovaj enzim takođe deluje na benzimidazol.


  1. ^ Friedmann, H.C. (1965). „Partial purification and properties of a single displacement trans-N-glycosidase“. J. Biol. Chem. 240: 413-418. PMID 14253445. 
  2. ^ Friedmann, H.C. and Fyfe, J.A. (1969). „Pseudovitamin B12 biosynthesis. Enzymatic formation of a new adenylic acid, 7-α-D-ribofuranosyladenine 5′-phosphate“. J. Biol. Chem. 244: 1667-1671. PMID 5780835. 
  3. ^ Fyfe, J.A. and Friedmann, H.C. (1969). „Vitamin B12 biosynthesis. Enzyme studies on the formation of the α-glycosidic nucleotide precursor“. J. Biol. Chem. 244: 1659-1666. PMID 4238408. 
  4. ^ Cameron, B., Blanche, F., Rouyez, M.C., Bisch, D., Famechon, A., Couder, M., Cauchois, L., Thibaut, D., Debussche, L. and Crouzet, J. (1991). „Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5′-phosphate) synthase“. J. Bacteriol. 173: 6066-6073. PMID 1917841. 
  5. ^ Cheong, C.G., Escalante-Semerena, J.C. and Rayment, I. (2001). „Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica“. J. Biol. Chem. 276: 37612-37620. PMID 11441022. 
  6. ^ Cheong, C.G., Escalante-Semerena, J.C. and Rayment, I. (2002). „Capture of a labile substrate by expulsion of water molecules from the active site of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica“. J. Biol. Chem. 277: 41120-41127. PMID 12101181. 


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