OR51E2

Olfaktorni receptor, familija 51, potfamilija E, član 2
Olfaktorni receptor, familija 51, potfamilija E, član 2
Identifikatori
Simboli	OR51E2; OR51E3P; OR52A2; PSGR
Vanjski ID	OMIM: 611268 MGI: 2157548 HomoloGene: 23713 GeneCards: OR51E2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora; • aktivnost olfaktornog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa membranom;
Biološki proces	• respons na stimulus;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	81285
Ensembl	ENSG00000167332
UniProt	Q9H255
RefSeq (mRNA)	NM_030774.3
RefSeq (protein)	NP_110401.1
Lokacija (UCSC)	Chr 11:; 4.7 - 4.72 Mb
PubMed pretraga	[1]

Olfaktorni receptor 51E2 je protein koji je kod ljudi kodiran OR51E2 genom.^[1]^[2]

Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.^[2]

Reference[уреди | уреди извор]

^ Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S (2000). „PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer”. Cancer Res. 60 (23): 6568—72. PMID 11118034.
^ ^а ^б „Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2”.

Literatura[уреди | уреди извор]

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Xu LL; Sun C; Petrovics G; et al. (2006). „Quantitative expression profile of PSGR in prostate cancer”. Prostate Cancer Prostatic Dis. 9 (1): 56—61. PMID 16231015. doi:10.1038/sj.pcan.4500836.
Wang J; Weng J; Cai Y; et al. (2006). „The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase”. Prostate. 66 (8): 847—57. PMID 16491480. doi:10.1002/pros.20389.