PD-102,807

Из Википедије, слободне енциклопедије
PD-102,807
(IUPAC) ime
etil 3,6a,11,14-tetrahidro-9-metoksi-2-metil-(12H)-izohino[1,2-b]pirolo[3,2-f][1,3]benzoksazin-1-karboksilat
Klinički podaci
Identifikatori
CAS broj 23062-91-1
ATC kod  ?
PubChem[1][2] 4995951
ChemSpider[3] 4175916
ChEMBL[4] CHEMBL59898 YesY
Hemijski podaci
Formula C23H24N2O4 
Mol. masa 392,447 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

PD-102,807 je lek koji deluje kao selektivni antagonist za muskarinski acetilholinski receptor M4.[5][6][7] On se koristi u naučnim istraživanjima za studiranje efekata različitih muskarinskih receptorskih podtipova u telu i mozgu.[8][9][10][11]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ^ Olianas MC, Onali P (1999). „PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP“. Life Sciences 65 (21): 2233–40. DOI:10.1016/S0024-3205(99)00488-9. PMID 10576595. 
  6. ^ Varoli L, Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Bedini A, Fazio N, Spampinato S (May 2008). „Diphenidol-related diamines as novel muscarinic M4 receptor antagonists“. Bioorganic & Medicinal Chemistry Letters 18 (9): 2972–6. DOI:10.1016/j.bmcl.2008.03.061. PMID 18395442. 
  7. ^ Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD (July 2002). „Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors“. Journal of Medicinal Chemistry 45 (14): 3094–102. DOI:10.1021/jm011116o. PMID 12086495. 
  8. ^ Pujol Lereis VA, Hita FJ, Gobbi MD, Verdi MG, Rodriguez MC, Rothlin RP (March 2006). „Pharmacological characterization of muscarinic receptor subtypes mediating vasoconstriction of human umbilical vein“. British Journal of Pharmacology 147 (5): 516–23. DOI:10.1038/sj.bjp.0706654. PMC 1616972. PMID 16444291. 
  9. ^ Hogan K, Markos F (February 2007). „Muscarinic type 1 receptors mediate part of nitric oxide's vagal facilitatory effect in the isolated innervated rat right atrium“. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society 16 (1): 110–7. DOI:10.1016/j.niox.2006.05.005. PMID 16843016. 
  10. ^ Myslivecek J, Klein M, Novakova M, Ricny J (July 2008). „The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles“. Naunyn-Schmiedeberg's Archives of Pharmacology 378 (1): 103–16. DOI:10.1007/s00210-008-0285-8. PMID 18443764. 
  11. ^ Lau BK, Vaughan CW (November 2008). „Muscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal gray“. Molecular Pharmacology 74 (5): 1392–8. DOI:10.1124/mol.108.045872. PMID 18678620. 

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