Panteteinska hidrolaza

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Panteteinska hidrolaza
EC broj
CAS broj 56093-18-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Panteteinska hidrolaza (EC, panteteinaza, vanin, vanin-1) je enzim sa sistematskim imenom (R)-pantetein amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

(R)-pantetein + H2O \rightleftharpoons (R)-pantotenat + 2-aminoetantiol

Ovaj enzim hidrolizuje jednu od amidnih veza panteteina.


  1. ^ Duprè, S. and Cavallini, D. (1979). „Purification and properties of pantetheinase from horse kidney“. Methods Enzymol. 62: 262-267. PMID 440106. 
  2. ^ Duprè, S., Chiaraluce, R., Nardini, M., Cannella, C., Ricci, G. and Cavallini, D. (1984). „Continuous spectrophotometric assay of pantetheinase activity“. Anal. Biochem. 142: 175-181. PMID 6549111. 
  3. ^ Maras, B., Barra, D., Duprè, S. and Pitari, G. (1999). „Is pantetheinase the actual identity of mouse and human vanin-1 proteins?“. FEBS Lett. 461: 149-152. PMID 10567687. 
  4. ^ Aurrand-Lions, M., Galland, F., Bazin, H., Zakharyev, V.M., Imhof, B.A. and Naquet, P. (1996). „Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing“. Immunity 5: 391-405. PMID 8934567. 
  5. ^ Pitari, G., Malergue, F., Martin, F., Philippe, J.M., Massucci, M.T., Chabret, C., Maras, B., Duprè, S., Naquet, P. and Galland, F. (2000). „Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice“. FEBS Lett. 483: 149-154. PMID 11042271. 
  6. ^ Martin, F., Malergue, F., Pitari, G., Philippe, J.M., Philips, S., Chabret, C., Granjeaud, S., Mattei, M.G., Mungall, A.J., Naquet, P. and Galland, F. (2001). „Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes“. Immunogenetics 53: 296-306. PMID 11491533. 
  7. ^ Pace, H.C. and Brenner, C. (2001). „The nitrilase superfamily: classification, structure and function“. Genome Biol. 2: 0001.-001.9. PMID 11380987. 


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