Peptidaza-1 (gnjida)

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Peptidaza-1 (gnjida)
Identifikatori
EC broj 3.4.22.65
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Peptidaza-1 (gnjida) (EC 3.4.22.65, alergen Der f 1, alergen Der p 1, antigen Der p 1, antigen Eur m 1, antigen Pso o 1, glavni vašni fekalni alergen Der p 1, Der p 1, Der f 1, Eur m 1, endopeptidaza 1 (vaš)) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Endopeptidazazno dejstvo sa širokom specifičnošću

Ovaj enzim, izveden iz kućne grinje, je glavna komponenta alergijskog imunog responsa.

Reference[уреди]

  1. ^ Meighan, P. and Pirzad, R. (2004). „Mite endopeptidase 1“. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. стр. 1187-1189. 
  2. ^ Kalsheker, N.A., Deam, S., Chambers, L., Sreedharan, S., Brocklehurst, K. and Lomas, D.A. (1996). „The house dust mite allergen Der, pp. 1 catalytically inactivates α1-antitrypsin by specific reactive centre loop cleavage: a mechanism that promotes airway inflammation and asthma“. Biochem. Biophys. Res. Commun. 221: 59-61. PMID 8660343. 
  3. ^ Harris, J., Mason, D.E., Li, J., Burdick, K.W., Backes, B.J., Chen, T., Shipway, A., Van Heeke, G., Gough, L., Ghaemmaghami, A., Shakib, F., Debaene, F. and Winssinger, N. (2004). „Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays“. Chem. Biol. 11: 1361-1372. PMID 15489163. 
  4. ^ Schulz, O., Sewell, H.F. and Shakib, F. (1998). „Proteolytic cleavage of CD25, the α subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity“. J. Exp. Med. 187: 271-275. PMID 9432986. 
  5. ^ Schulz, O., Sewell, H.F. and Shakib, F. (1998). „A sensitive fluorescent assay for measuring the cysteine protease activity of Der p 1, a major allergen from the dust mite Dermatophagoides pteronyssinus“. Mol. Pathol. 51: 222-224. PMID 9893750. 
  6. ^ Takai, T., Kato, T., Sakata, Y., Yasueda, H., Izuhara, K., Okumura, K. and Ogawa, H. (2005). „Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity“. Biochem. Biophys. Res. Commun. 328: 944-952. PMID 15707969. 

Литература[уреди]

  • Meighan, P. and Pirzad, R. (2004). „Mite endopeptidase 1“. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. стр. 1187-1189. 

Spoljašnje veze[уреди]