Pirimidin oksigenaza
| Pirimidin oksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.46 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Pirimidin oksigenaza (EC 1.14.99.46, RUTA) je enzim sa sistematskim imenom uracil,FMNH2:kiseonik oksidoreduktaza (uracilna hidroksilacija, otvaranje prstena).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) uracil + FMNH2 + O2 (Z)-3-ureidoakrilatna perkiselina + FMN
- (2) timin + FMNH}-2 + O2 (Z)-2-metilureidoakrilatna perkiselina + FMN
In vitro se produkt (Z)-3-ureidoakrilat perkiselina spontano redukuje do ureidoakrilata.
Reference[уреди | уреди извор]
- ^ Mukherjee, T., Zhang, Y., Abdelwahed, S., Ealick, S.E. and Begley, T.P. (2010). „Catalysis of a flavoenzyme-mediated amide hydrolysis”. J. Am. Chem. Soc. 132: 5550—5551. PMID 20369853.
- ^ Kim, K.S., Pelton, J.G., Inwood, W.B., Andersen, U., Kustu, S. and Wemmer, D.E. (2010). „The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems”. J. Bacteriol. 192: 4089—4102. PMID 20400551.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Pyrimidine+oxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
