Propilnorapomorfin

Из Википедије, слободне енциклопедије
Propilnorapomorfin
(IUPAC) ime
(6aS)-6-propil-5,6,6a,7-tetrahidro-4H-dibenzo[de,g]hinolin-10,11-diol
Klinički podaci
Identifikatori
CAS broj 57559-68-9
ATC kod nije dodeljen
PubChem[1][2] 5311191
ChemSpider[3] 4470712
Hemijski podaci
Formula C19H21NO2 
Mol. masa 295,38 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Uncontrolled
Način primene Oralno

N-n-Propilnorapomorfin (NPA) je derivat aporfina koji deluje kao dopaminski agonist. On je blisko srodan sa apomorfinom.[4][5] Pokazano je da kod glodara između ostalog proizvodi hiperaktivnost, stereotipiju, hipotermiju, antinocepciju, i erekciju.[6][7][8][9]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Miller RJ, Kelly PH, Neumeyer JL (January 1976). „Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain“. European Journal of Pharmacology 35 (1): 77–83. DOI:10.1016/0014-2999(76)90302-2. PMID 943290. 
  5. ^ Creese I, Padgett L, Fazzini E, Lopez F (July 1979). „3H-N-n-propylnorapomorphine: a novel agonist ligand for central dopamine receptors“. European Journal of Pharmacology 56 (4): 411–2. DOI:10.1016/0014-2999(79)90274-7. PMID 477735. 
  6. ^ Menon MK, Clark WG, Neumeyer JL (November 1978). „Comparison of the dopaminergic effects of apomorphine and (-)-N-n-propylnorapomorphine“. European Journal of Pharmacology 52 (1): 1–9. DOI:10.1016/0014-2999(78)90015-8. PMID 569056. 
  7. ^ Riffee WH, Wilcox RE, Smith RV (March 1979). „Stereotypic and hypothermic effects of apomorphine and N-n-propylnorapomorphine in mice“. European Journal of Pharmacology 54 (3): 273–7. DOI:10.1016/0014-2999(79)90086-4. PMID 570924. 
  8. ^ Neumeyer JL, Reinhard JF, Dafeldecker WP, et al. (January 1976). „Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-n-propylnoraporphine“. Journal of Medicinal Chemistry 19 (1): 25–9. DOI:10.1021/jm00223a006. PMID 942751. 
  9. ^ Benassi-Benelli A, Ferrari F, Quarantotti BP (December 1979). „Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats“. Archives Internationales De Pharmacodynamie Et De Thérapie 242 (2): 241–7. PMID 44457. 

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