Psilocibin
Из Википедије, слободне енциклопедије
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| Klinički podaci | |
|---|---|
| Identifikatori | |
| CAS broj | 520-52-5 |
| ATC kod | nije dodeljen |
| PubHem | 10624 |
| HemSpider | 10178 |
| KEGG | C07576  |
| ChEMBL | CHEMBL194378 |
| Hemijski podaci | |
| Formula | C12H17N2O4P |
| Mol. masa | 284.25 g/mol |
| SMILES | eMolekuli & PubHem |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | Zabranjena supstanca (S9) (AU) Schedule III (CA) ? (UK) Schedule I (SAD) |
Psilocibin (ili 4-PO-DMT) je halucinogeni sastojak prisutan u velikom broju gljiva iz porodice Psilociba, koje se u žarogonu zovu magične gljive.[1] U nekim plemenskim kulturama gljive se uživaju u religiozno-mistične svrhe. Danas je uživanje psilociba, iako u nekim zemljama nezakonito, sve više rasprostranjeno u zapadnom svetu.
Psilocibin je izuzetno aktivna materija.[2][3] Efekti psilocibina se porede sa efektima LSD-a, samo kraćeg trajanja. Prvi efekti se javljaju već pri dozi od 4 mg. Simptomi nastaju 0,5 - 2 časa nakon uzimanja, a sastoje se od glavobolje, vrtoglavice, mišićne slabosti, usporenja pulsa i sniženja krvnog pritiska i psihoznih efekata koji mogu biti ugodni, ali i neugodni. Pojavljuju se halucinacija i poremećaj percepcije vremena i prostora a nekad i euforija ili depresija. Efekti obično traju 6 do 10 časova.
Садржај |
Izvori [уреди]
- ^ Beck O, Helander A, Karlson-Stiber C, Stephansson N. (1998). „Presence of phenylethylamine in hallucinogenic Psilocybe mushroom: possible role in adverse reactions“. Journal of Analytical Toxicology 22 (1): 45–9. PMID 9491968.
- ^ Abramson HA, Rolo A. (1965). „Lysergic acid diethylamide (LSD-25). 38. Comparison with action of methysergide and psilocybin on test subjects“. The Journal of Asthma Research 3 (1): 81–96. DOI:10.3109/02770906509106904. PMID 5318626.
- ^ Adams JD Jr. (2009). „Chemical Interactions with pyramidal neurons in layer 5 of the cerebral cortex: control of pain and anxiety“. Current Medicinal Chemistry 16 (27): 3476–9. DOI:10.2174/092986709789057626. PMID 19799545.
Dodatna literatura [уреди]
- Boire RG. (2002). Sacred Mushrooms and the Law. Berkeley, California: Ronin Publishing. ISBN 978-1579510619.
- Doblin R. (1991). „Pahnke's "Good Friday Experiment": A long-term follow-up and methodological critique“ (PDF). Journal of Transpersonal Psychology 23 (1): 1–25.
- Marley G. (2010). „Chapter 13. Psilocybin: Gateway to the Soul or Just a Good High?“. Chanterelle Dreams, Amanita Nightmares: The Love, Lore, and Mystique of Mushrooms. White River Junction, Vermont: Chelsea Green Publishing. стр. 163–84. ISBN 1-60358-214-2.
- Ott J. (1993). Pharmacotheon Entheogenic Drugs Their Plant Sources and Histories. Kennewick, Washington: Natural Products Company. ISBN 978-0961423438.
- Stafford PJ. (1992). Psychedelics Encyclopedia. Berkeley, California: Ronin Publishing. ISBN 0-914171-51-8.
- Stamets P. (1996). Psilocybin Mushrooms of the World: An Identification Guide. Berkeley, California: Ten Speed Press. ISBN 0-89815-839-7.
2006 Džon Hopkins eksperimenti [уреди]
- "Hopkins Scientists Show Hallucinogen in Mushrooms Creates Universal 'Mystical' Experience", Johns Hopkins Medicine news release, July 11, 2006.
- "Q&A is with Roland Griffiths, the study’s lead researcher", Johns Hopkins Medicine news release, July 11, 2006.
- "Psilocybin Viewed as Therapy or Research Tool" by Michael Smith, Medpagetoday.com, July 12, 2006.
- "Magic mushrooms really cause 'spiritual' experiences" by Roxanne Khamsi, New Scientist news service, July 11, 2006.
- "Drug's Mystical Properties Confirmed" by David Brown, Washington Post, July 11, 2006.
- "Mushroom Drug Produces Mystical Experience", Associated Press, July 11, 2006.
- "Counterculture Drug Provides Spiritual Boost" by Denise Gellene, Los Angeles Times, July 11, 2006.
- "Tripping Out: Scientists Study Mystical Effects of Mushrooms" by Joy Victory, Bharathi Radhakrishnan, and Andrea Carter, ABC News (online), July 11, 2006. ABC News video report of the study.
2008 Nastavak Džon Hopkins eksperimenta [уреди]
- "A Very Memorable Trip", by Greg Miller, ScienceNOW Daily News, July 1, 2008
- "Spiritual Effects of Hallucinogens Persist, Johns Hopkins Researchers Report", Johns Hopkins Medicine news release, July 1, 2008.
- "Psilocybin Study Hints at Rebirth of Hallucinogen Research", by Brandon Keim, "Wired," July 1, 2008
- "Sacred Intentions: Inside the Johns Hopkins Psilocybin Studies" by Michael M. Hughes, Baltimore City Paper, October 8, 2008.
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