Romboidna proteaza

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Romboidna proteaza
EC broj
CAS broj 713145-02-9
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Romboidna proteaza (EC je enzim.[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje tip-1 transmembranskog domena koristeći katalitički par koji se sastoji od serina i histidina koji pripadaju različitim transmembranskim domenima

Ova endopeptidaza je membranski protein koji ima više prolaza kroz membranu.


  1. ^ Urban, S. and Wolfe, M.S. (2005). „Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity“. Proc. Natl. Acad. Sci. USA 102: 1883-1888. PMID 15684070. 
  2. ^ Brossier, F., Jewett, T.J., Sibley, L.D. and Urban, S. (2005). „A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma“. Proc. Natl. Acad. Sci. USA 102: 4146-4151. PMID 15753289. 
  3. ^ Herlan, M., Bornhovd, C., Hell, K., Neupert, W. and Reichert, A.S. (2004). „Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor“. J. Cell Biol. 165: 167-173. PMID 15096522. 
  4. ^ Pascall, J.C. and Brown, K.D. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL (2004). „2“. Biochem. Biophys. Res. Commun. 317: 244-252. PMID 15047175. 
  5. ^ Sik, A., Passer, B.J., Koonin, E.V. and Pellegrini, L. (2004). „Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pβ, a nuclear-targeted peptide“. J. Biol. Chem. 279: 15323-15329. PMID 14732705. 
  6. ^ Urban, S. and Freeman, M. (2003). „Substrate specificity of Rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol“. Cell 11: 1425-1434. PMID 12820957. 
  7. ^ Herlan, M., Vogel, F., Bornhovd, C., Neupert, W. and Reichert, A.S. (2003). „Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA“. J. Biol. Chem. 278: 27781-27788. PMID 12707284. 
  8. ^ McQuibban, G.A., Saurya, S. and Freeman, M. (2003). „Mitochondrial membrane remodelling regulated by a conserved rhomboid protease“. Nature 423: 537-541. PMID 12774122. 
  9. ^ Koonin, E.V., Makarova, K.S., Rogozin, I.B., Davidovic, L., Letellier, M.C. and Pellegrini, L. (2003). „The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers“. Genome Biol. 4: R19-R19. PMID 12620104. 
  10. ^ Urban, S. and Freeman, M. (2002). „Intramembrane proteolysis controls diverse signalling pathways throughout evolution“. Curr. Opin. Genet. Dev. 12: 512-518. PMID 12200155. 
  11. ^ Urban, S., Schlieper, D. and Freeman, M. (2002). „Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic Rhomboids“. Curr. Biol. 12: 1507-1512. PMID 12225666. 
  12. ^ Urban, S., Lee, J.R. and Freeman, M. (2002). „A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF-like ligands“. EMBO J. 21: 4277-4286. PMID 12169630. 
  13. ^ Urban, S., Lee, J.R. and Freeman, M. (2001). „Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases“. Cell 107: 173-182. PMID 11672525. 
  14. ^ Lemberg, M.K., Menendez, J., Misik, A., Garcia, M., Koth, C.M. and Freeman, M. (2005). „Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases“. EMBO J. 24: 464-472. PMID 15616571. 
  15. ^ Wang, Y., Zhang, Y. and Ha, Y. (2006). „Crystal structure of a rhomboid family intramembrane protease“. Nature 444: 179-180. PMID 17051161. 


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