SB-357,134

Из Википедије, слободне енциклопедије
SB-357,134
(IUPAC) ime
N-(2,5-Dibromo-3-fluorofenil)-4-metoksi-3-(1-piperazinil)benzensulfonamid
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 6918553
ChEMBL[3] CHEMBL329383 YesY
Hemijski podaci
Formula C17H18Br2FN3O3S 
Mol. masa 523,214 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

SB-357,134 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan, selektivan i oralno aktivan antagonist 5-HT6 receptora.[4] SB-357,134 i drugi 5-HT6 antagonisti manifestuju nootropne efekte u životinjskim studijama,[5][6][7] i potencijalno mogu da služe kao treatmen za kognitivne poremećaje kao što su šizofrenija i Alchajmerova bolest.

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  4. ^ Bromidge, SM; Clarke, SE; Gager, T; Griffith, K; Jeffrey, P; Jennings, AJ; Joiner, GF; King, FD et al. (2001). „Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)“. Bioorganic & Medicinal Chemistry Letters 11 (1): 55–8. DOI:10.1016/S0960-894X(00)00597-7. PMID 11140733. 
  5. ^ Rogers, DC; Hagan, JJ (2001). „5-HT6 receptor antagonists enhance retention of a water maze task in the rat“. Psychopharmacology 158 (2): 114–9. DOI:10.1007/s002130100840. PMID 11702084. 
  6. ^ Stean, TO; Hirst, WD; Thomas, DR; Price, GW; Rogers, D; Riley, G; Bromidge, SM; Serafinowska, HT et al. (2002). „Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist“. Pharmacology, Biochemistry, and Behavior 71 (4): 645–54. DOI:10.1016/S0091-3057(01)00742-0. PMID 11888556. 
  7. ^ Perez-García, G; Meneses, A (2005). „Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task“. Pharmacology, Biochemistry, and Behavior 81 (3): 673–82. DOI:10.1016/j.pbb.2005.05.005. PMID 15964617. 

Spoljašnje veze[уреди]