Senecionin N-oksigenaza
| Senecionin N-oksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.101 | ||||||||
| CAS broj | 220581-68-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Senecionin N-oksigenaza (EC 1.14.13.101, senecionin monooksigenaza (formira N-oksid), SNO) je enzim sa sistematskim imenom senecionin,NADPH:kiseonik oksidoreduktaza (formira N-oksid).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- senecionin + NADPH + H+ + O2 senecionin N-oksid + NADP+ +H2O
Ovaj enzim je flavoprotein. On može da koristi NADH umesto NADPH.
Reference[уреди | уреди извор]
- ^ Lindigkeit, R., Biller, A., Buch, M., Schiebel, H.M., Boppre, M. and Hartmann, T. (1997). „The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids”. Eur. J. Biochem. 245: 626—636. PMID 9182998.
- ^ Naumann, C., Hartmann, T. and Ober, D. (2002). „Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae”. Proc. Natl. Acad. Sci. USA. 99: 6085—6090. PMID 11972041.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Senecionine+N-oxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
