Serinska peptidaza ekvinskog arterivirusa
| Serinska peptidaza ekvinskog arterivirusa | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.114 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Serinska peptidaza ekvinskog arterivirusa (EC 3.4.21.114, Equine arterivirus serine peptidase) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Presecanje (Glu/Gln)-(Gly/Ser/Ala) u translacionim produktima arterivirusne replikaze ORF1a i ORF1ab
U konjskom arterivirusu (EAV), gen replikaze se translira u otvorene okvire čitanja 1a (ORF1a) i ORF1ab poliproteina.
Reference[уреди | уреди извор]
- ^ Snijder, E.J., Wassenaar, A.L., van Dinten, L.C., Spaan, W.J. and Gorbalenya, A.E. (1996). „The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases”. J. Biol. Chem. 271: 4864—4871. PMID 8617757.
- ^ van Dinten, L.C., Rensen, S., Gorbalenya, A.E. and Snijder, E.J. (1999). „Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and is essential for virus replication”. J. Virol. 73: 2027—2037. PMID 9971783.
- ^ Barrette-Ng, I.H., Ng, K.K., Mark, B.L., Van Aken, D., Cherney, M.M., Garen, C., Kolodenko, Y., Gorbalenya, A.E., Snijder, E.J. and James, M.N. (2002). „Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an α/β C-terminal extension and alternate conformations of the oxyanion hole”. J. Biol. Chem. 277: 39960—39966. PMID 12163505.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Equine+arterivirus+serine+peptidase на US National Library of Medicine Medical Subject Headings (MeSH)
