T-Plasminogeni aktivator

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T-Plasminogeni aktivator
Protein PLAT PDB 1a5h.png
Identifikatori
EC broj 3.4.21.68
CAS broj 139639-23-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

T-Plasminogeni aktivator (EC 3.4.21.68, tkivni plazminogenski activator, plazminogenski aktivator, tkivni-tip, tkivni tip plazminogenskog aktivatora, tPA, t-PA) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Specifično razlaganje Arg-Val veze u plazminogenu čime se formira plazmin

Ova peptidaza je prisutna u širokom opsegu tipova tkiva, a posebno u endotelnim ćelijama.

Reference[уреди]

  1. ^ Pennica, D., Holmes, W.E., Kohr, W.J., Harkins, R.N., Vehar, G.A., Ward, C.A., Bennett, W.F., Yelverton, E., Seeburg, P.H., Heyneker, H.L., Goeddel, D.V. and Collen, D. (1983). „Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli“. Nature 301: 214-221. PMID 6337343. 
  2. ^ Loskutoff, D.J. and Schleef, R.R. (1988). „Plasminogen activators and their inhibitors“. Methods Enzymol. 163: 293-302. PMID 3148826. 
  3. ^ Petersen, L.C., Johannessen, M., Forster, D., Kumar, A. and Mulvihill, E. (1988). „The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage“. Biochim. Biophys. Acta 952: 245-254. PMID 2962643. 
  4. ^ Verheijen, J.H. (1988). „Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma“. Methods Enzymol. 163: 302-309. PMID 3148827. 
  5. ^ Gerard, R.D. and Meidell, R.S. (1989). „Regulation of tissue plasminogen activator expression“. Annu. Rev. Physiol. 51: 245-262. PMID 2496643. 
  6. ^ Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders“. In Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd ed.). Philadelphia: J.B.Lippincott Company. стр. -. 

Литература[уреди]

  • Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders“. In Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd ed.). Philadelphia: J.B.Lippincott Company. стр. -. 

Spoljašnje veze[уреди]