TRIO (gen)

Из Википедије, слободне енциклопедије
Faktor razmene trio ro guanina

PDB prikaz baziran na 1nty.
Dostupne strukture
1NTY, 2NZ8
Identifikatori
Simboli TRIO; ARHGEF23; tgat
Vanjski ID OMIM601893 MGI1927230 HomoloGene20847 GeneCards: TRIO Gene
EC broj 2.7.11.1
Pregled RNK izražavanja
PBB GE TRIO 209012 at tn.png
PBB GE TRIO 208178 x at tn.png
PBB GE TRIO 209010 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 7204 223435
Ensembl ENSG00000038382 ENSMUSG00000022263
UniProt O75962 Q0KL02
RefSeq (mRNA) NM_007118.2 NM_001081302.1
RefSeq (protein) NP_009049.2 NP_001074771.1
Lokacija (UCSC) Chr 5:
14.14 - 14.53 Mb
Chr 15:
27.73 - 28.03 Mb
PubMed pretraga [1] [2]

Protein trofunkcionog domena (engl. Triple functional domain protein) je protein koji je kod ljudi kodiran TRIO genom.[1][2]

Interakcije[уреди]

TRIO (gen) formira interakcije sa filaminom[3] i RHOA.[4]

Reference[уреди]

  1. ^ Debant A, Serra-Pages C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (July 1996). „The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains“. Proc Natl Acad Sci U S A 93 (11): 5466–71. DOI:10.1073/pnas.93.11.5466. PMC 39269. PMID 8643598. 
  2. ^ „Entrez Gene: TRIO triple functional domain (PTPRF interacting)“. 
  3. ^ Bellanger, J M; Astier C, Sardet C, Ohta Y, Stossel T P, Debant A (December 2000). „The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin“. Nat. Cell Biol. (ENGLAND) 2 (12): 888–92. DOI:10.1038/35046533. ISSN 1465-7392. PMID 11146652. 
  4. ^ Medley, Q G; Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien S P, Streuli M (November 2000). „The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain“. J. Biol. Chem. (UNITED STATES) 275 (46): 36116–23. DOI:10.1074/jbc.M003775200. ISSN 0021-9258. PMID 10948190. 

Literatura[уреди]