Timopoietin

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Timopoietin

PDB prikaz baziran na 1gjj.
Dostupne strukture
1GJJ, 1H9E, 1H9F
Identifikatori
Simboli TMPO; CMD1T; LAP2; LEMD4; PRO0868; TP
Vanjski ID OMIM188380 MGI106920 HomoloGene31144 GeneCards: TMPO Gene
Pregled RNK izražavanja
PBB GE TMPO 209753 s at tn.png
PBB GE TMPO 209754 s at tn.png
PBB GE TMPO 203432 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 7112 21917
Ensembl ENSG00000120802 ENSMUSG00000019961
UniProt P42166 Q61029
RefSeq (mRNA) NM_001032283.2 NM_001080129.1
RefSeq (protein) NP_001027454.1 NP_001073598.1
Lokacija (UCSC) Chr 12:
98.91 - 98.94 Mb
Chr 10:
91.15 - 91.17 Mb
PubMed pretraga [1] [2]

Timopoietin (polipeptid vezan za laminu 2, LAP2) je protein koji je kod ljudi kodiran TMPO genom.[1][2] LAP2 je protein unutrašnje membrane jedra.[3]

Timopoietin učestvuje u indukciji CD90 proteina u grudnu žlezdu. Gen timopoetina kodira tri alternativno splajsovane iRNK molekula koji kodiraju proteine sa 75 kDa (alfa), 51 kDa (beta) i 39 kDa (gama). Oni su izraženi u većini ćelijskih tipova. Ljudski TMPO gen se nalazi u hromozomsko opsegu 12q22 i sastoji se od osam eksona.

Interakcije[уреди]

Timopoietin formira interakcije sa barijerom za autointegracioni faktor 1,[4] AKAP8L,[5][6] LMNB1[7][8] i LMNA.[9][10]

Reference[уреди]

  1. ^ Harris CA, Andryuk PJ, Cline S, Chan HK, Natarajan A, Siekierka JJ, Goldstein G (August 1994). „Three distinct human thymopoietins are derived from alternatively spliced mRNAs“. Proc Natl Acad Sci U S A 91 (14): 6283–7. DOI:10.1073/pnas.91.14.6283. PMC 44185. PMID 7517549. 
  2. ^ „Entrez Gene: TMPO thymopoietin“. 
  3. ^ PMID 11766875 (PubMed)
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  4. ^ Furukawa, K (August 1999). „LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction“. J. Cell. Sci. (ENGLAND) 112 (15): 2485–92. ISSN 0021-9533. PMID 10393804. 
  5. ^ Martins, S B; Eide T, Steen R L, Jahnsen T, Skålhegg B S, Collas P (November 2000). „HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics“. J. Cell. Sci. (ENGLAND) 113 (21): 3703–13. ISSN 0021-9533. PMID 11034899. 
  6. ^ Martins, Sandra; Eikvar Sissel, Furukawa Kazuhiro, Collas Philippe (January 2003). „HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication“. J. Cell Biol. (United States) 160 (2): 177–88. DOI:10.1083/jcb.200210026. ISSN 0021-9525. PMC 2172640. PMID 12538639. 
  7. ^ Furukawa, K; Kondo T (February 1998). „Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin“. Eur. J. Biochem. (GERMANY) 251 (3): 729–33. DOI:10.1046/j.1432-1327.1998.2510729.x. ISSN 0014-2956. PMID 9490046. 
  8. ^ Foisner, R; Gerace L (July 1993). „Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation“. Cell (UNITED STATES) 73 (7): 1267–79. DOI:10.1016/0092-8674(93)90355-T. ISSN 0092-8674. PMID 8324822. 
  9. ^ Markiewicz, Ewa; Dechat Thomas, Foisner Roland, Quinlan Roy A, Hutchison Christopher J (December 2002). „Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein“. Mol. Biol. Cell (United States) 13 (12): 4401–13. DOI:10.1091/mbc.E02-07-0450. ISSN 1059-1524. PMC 138642. PMID 12475961. 
  10. ^ Dechat, T; Korbei B, Vaughan O A, Vlcek S, Hutchison C J, Foisner R (October 2000). „Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins“. J. Cell. Sci. (ENGLAND) 113 (19): 3473–84. ISSN 0021-9533. PMID 10984438. 

Literatura[уреди]

Spoljašnje veze[уреди]