Tromboksan-A sintaza

Tromboksan A sintaza 1 (trombocitna)
Identifikatori
Simboli	TBXAS1; BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
Vanjski ID	OMIM: 274180 MGI: 98497 HomoloGene: 55549 GeneCards: TBXAS1 Gene
EC broj	5.3.99.5
Ontologija gena Molekularna funkcija • aktivnost monooksigenaze • aktivnost tromboksan-A sintaze • vezivanje jona gvožđa • aktivnost nosača elektrona Celularna komponenta • membrana endoplazmičnog retikuluma • integralno sa membranom Biološki proces • proces prostaglandinske biosinteze • proces eikozanoidnog metabolizma • proces ksenobiotičkog metabolizma
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	6916	21391
Ensembl	ENSG00000059377	ENSMUSG00000029925
UniProt	P24557	P36423
RefSeq (mRNA)	NM_001061.4	NM_011539.3
RefSeq (protein)	NP_001052.2	NP_035669.3
Lokacija (UCSC)	Chr 7: 139.48 - 139.72 Mb	Chr 6: 38.88 - 39.08 Mb
PubMed pretraga	[1]	[2]

Tromboksan-A sintaza 1 (trombocit, citohrom P450, familija 5, potfamilija A), takođe poznata kao TBXAS1, je enzim koji je kod ljudi kodiran TBXAS1 genom.

Literatura

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• Wang LH, Kulmacz RJ (2003). „Thromboxane synthase: structure and function of protein and gene“. Prostaglandins Other Lipid Mediat. 68-69: 409–422. DOI:10.1016/S0090-6980(02)00045-X. PMID 12432933. 
• Itoh S, Yanagimoto T, Tagawa S et al. (1992). „Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region“. Biochim. Biophys. Acta 1130 (2): 133–8. PMID 1562592. 
• Yokoyama C, Miyata A, Ihara H et al. (1991). „Molecular cloning of human platelet thromboxane A synthase“. Biochem. Biophys. Res. Commun. 178 (3): 1479–1484. DOI:10.1016/0006-291X(91)91060-P. PMID 1714723. 
• Ohashi K, Ruan KH, Kulmacz RJ et al. (1992). „Primary structure of human thromboxane synthase determined from the cDNA sequence“. J. Biol. Chem. 267 (2): 789–93. PMID 1730669. 
• Jones DA, Fitzpatrick FA, Malcolm KC (1991). „Thromboxane A2 synthesis in human erythroleukemia cells“. Biochem. Biophys. Res. Commun. 180 (1): 8–14. DOI:10.1016/S0006-291X(05)81247-1. PMID 1930241. 
• Wang LH, Ohashi K, Wu KK (1991). „Isolation of partial complementary DNA encoding human thromboxane synthase“. Biochem. Biophys. Res. Commun. 177 (1): 286–291. DOI:10.1016/0006-291X(91)91980-Q. PMID 2043115. 
• Nüsing R, Schneider-Voss S, Ullrich V (1990). „Immunoaffinity purification of human thromboxane synthase“. Arch. Biochem. Biophys. 280 (2): 325–330. DOI:10.1016/0003-9861(90)90337-X. PMID 2195994. 
• Mestel F, Oetliker O, Beck E et al. (1980). „Severe bleeding associated with defective thromboxane synthetase“. Lancet 1 (8160): 157. DOI:10.1016/S0140-6736(80)90642-X. PMID 6101498. 
• Miyata A, Yokoyama C, Ihara H et al. (1994). „Characterization of the human gene (TBXAS1) encoding thromboxane synthase“. Eur. J. Biochem. 224 (2): 273–279. DOI:10.1111/j.1432-1033.1994.00273.x. PMID 7925341. 
• Wang LH, Tazawa R, Lang AQ, Wu KK (1995). „Alternate splicing of human thromboxane synthase mRNA“. Arch. Biochem. Biophys. 315 (2): 273–278. DOI:10.1006/abbi.1994.1500. PMID 7986068. 
• Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides“. Gene 138 (1–2): 171–174. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Lee KD, Baek SJ, Shen RF (1994). „Cloning and characterization of the human thromboxane synthase gene promoter“. Biochem. Biophys. Res. Commun. 201 (1): 379–387. DOI:10.1006/bbrc.1994.1712. PMID 8198598. 
• Chase MB, Baek SJ, Purtell DC et al. (1993). „Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization“. Genomics 16 (3): 771–773. DOI:10.1006/geno.1993.1264. PMID 8325653. 
• Ruan KH, Wang LH, Wu KK, Kulmacz RJ (1993). „Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum“. J. Biol. Chem. 268 (26): 19483–90. PMID 8366093. 
• Tazawa R, Green ED, Ohashi K et al. (1996). „Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter“. Arch. Biochem. Biophys. 334 (2): 349–356. DOI:10.1006/abbi.1996.0464. PMID 8900410. 
• Baek SJ, Lee KD, Shen RF (1996). „Genomic structure and polymorphism of the human thromboxane synthase-encoding gene“. Gene 173 (2): 251–256. DOI:10.1016/0378-1119(95)00881-0. PMID 8964509. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library“. Gene 200 (1–2): 149–156. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149. 

Vidi još

• Prostanoid

Spoljašnje veze

• MeSH Thromboxane-A+Synthase