XPB

Из Википедије, слободне енциклопедије
Identifikatori
Simboli ERCC3; BTF2; GTF2H; RAD25; TFIIH; XPB
Vanjski ID OMIM133510 MGI95414 HomoloGene96 GeneCards: ERCC3 Gene
EC broj 3.6.4.12
Pregled RNK izražavanja
PBB GE ERCC3 202176 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2071 13872
Ensembl ENSG00000163161 ENSMUSG00000024382
UniProt P19447 P49135
RefSeq (mRNA) NM_000122.1 NM_133658.1
RefSeq (protein) NP_000113.1 NP_598419.1
Lokacija (UCSC) Chr 2:
128.01 - 128.05 Mb
Chr 18:
32.4 - 32.43 Mb
PubMed pretraga [1] [2]

XPB (Xeroderma Pigmentosum B) je ATP zavisna ljudska DNK helikaza koja je deo kompleksa TFIIH transkripcionog faktora. 3D struktura XPB homologa je kristalografski.[1]

Funkcija[уреди]

XPB učestvuje u normalnoj bazalnoj transkripciji, transkripciono spregnutoj popravci (TCR), i popravci isecanjem nukleotida (NER). Pokazano jed a prečišćeni XPB razvija DNK u 3’-5’ pravcu.

Interakcije[уреди]

XPB formira interakcije sa XPC,[2] BCR genom,[3] ERCC2,[4][5][6][7] P53,[8] GTF2H2,[4][5] GTF2H1,[4][5][9] GTF2H5,[4] ciklin zavisnom kinazom,[4][9][10] PSMC5[11] i GTF2H4.[4][5]

Literatura[уреди]

Reference[уреди]

  1. ^ Fan L, Arvai A, Cooper P, Iwai S, Hanaoka F, Tainer J (2006). „Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair“. Mol Cell 22 (1): 27–37. DOI:10.1016/j.molcel.2006.02.017. PMID 16600867. 
  2. ^ Yokoi, M; Masutani C, Maekawa T, Sugasawa K, Ohkuma Y, Hanaoka F (March 2000). „The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA“. J. Biol. Chem. (UNITED STATES) 275 (13): 9870–5. DOI:10.1074/jbc.275.13.9870. ISSN 0021-9258. PMID 10734143. 
  3. ^ Takeda, N; Shibuya M, Maru Y (January 1999). „The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein“. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (1): 203–7. DOI:10.1073/pnas.96.1.203. ISSN 0027-8424. PMC 15117. PMID 9874796. 
  4. ^ а б в г д ђ Giglia-Mari, Giuseppina; Coin Frederic, Ranish Jeffrey A, Hoogstraten Deborah, Theil Arjan, Wijgers Nils, Jaspers Nicolaas G J, Raams Anja, Argentini Manuela, van der Spek P J, Botta Elena, Stefanini Miria, Egly Jean-Marc, Aebersold Ruedi, Hoeijmakers Jan H J, Vermeulen Wim (July 2004). „A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A“. Nat. Genet. (United States) 36 (7): 714–9. DOI:10.1038/ng1387. ISSN 1061-4036. PMID 15220921. 
  5. ^ а б в г Marinoni, J C; Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez D M, Hoeijmakers J H, Egly J M (March 1997). „Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH“. EMBO J. (ENGLAND) 16 (5): 1093–102. DOI:10.1093/emboj/16.5.1093. ISSN 0261-4189. PMC 1169708. PMID 9118947. 
  6. ^ Drapkin, R; Reardon J T, Ansari A, Huang J C, Zawel L, Ahn K, Sancar A, Reinberg D (April 1994). „Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II“. Nature (ENGLAND) 368 (6473): 769–72. DOI:10.1038/368769a0. ISSN 0028-0836. PMID 8152490. 
  7. ^ Iyer, N; Reagan M S, Wu K J, Canagarajah B, Friedberg E C (February 1996). „Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein“. Biochemistry (UNITED STATES) 35 (7): 2157–67. DOI:10.1021/bi9524124. ISSN 0006-2960. PMID 8652557. 
  8. ^ Wang, X W; Yeh H, Schaeffer L, Roy R, Moncollin V, Egly J M, Wang Z, Freidberg E C, Evans M K, Taffe B G (June 1995). „p53 modulation of TFIIH-associated nucleotide excision repair activity“. Nat. Genet. (UNITED STATES) 10 (2): 188–95. DOI:10.1038/ng0695-188. ISSN 1061-4036. PMID 7663514. 
  9. ^ а б Rossignol, M; Kolb-Cheynel I, Egly J M (April 1997). „Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH“. EMBO J. (ENGLAND) 16 (7): 1628–37. DOI:10.1093/emboj/16.7.1628. ISSN 0261-4189. PMC 1169767. PMID 9130708. 
  10. ^ Yee, A; Nichols M A, Wu L, Hall F L, Kobayashi R, Xiong Y (December 1995). „Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor“. Cancer Res. (UNITED STATES) 55 (24): 6058–62. ISSN 0008-5472. PMID 8521393. 
  11. ^ Weeda, G; Rossignol M, Fraser R A, Winkler G S, Vermeulen W, van 't Veer L J, Ma L, Hoeijmakers J H, Egly J M (June 1997). „The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor“. Nucleic Acids Res. (ENGLAND) 25 (12): 2274–83. DOI:10.1093/nar/25.12.2274. ISSN 0305-1048. PMC 146752. PMID 9173976. 

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