Citidilat kinaza
Изглед
(преусмерено са EC 2.7.4.14)
Citidilat kinaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.7.4.14 | ||||||||
CAS broj | 37278-21-0 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Citidilat kinaza (EC 2.7.4.14, citidilatna kinaza, dezoksicitidilatna kinaza, CTP:CMP fosfotransferaza, dCMP kinaza, dezoksicitidinska monofosfokinaza, UMP-CMP kinaza, ATP:UMP-CMP fosfotransferaza, pirimidin nukleozid monofosfatna kinaza, uridin monofosfat-citidin monofosfatna fosfotransferaza) je enzim sa sistematskim imenom ATP:CMP(UMP) fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj eukariotski enzim je bifunkcionalan. On katalizuje fosforilaciju CMP i UMP molekula sa sličnom efikasnošću.
Reference[уреди | уреди извор]
- ^ Hurwitz, J. (1959). „The enzymatic incorporation of ribonucleotides into polydeoxynucleotide material”. J. Biol. Chem. 234: 2351—2358. PMID 14405566.
- ^ Ruffner, B.W., Jr. & Anderson, E.P. (1969). „Adenosine triphosphate: uridine monophosphate-cytidine monophosphate phosphotransferase from Tetrahymena pyriformis”. J. Biol. Chem. 244: 5994—6002. PMID 5350952.
- ^ Scheffzek, K., Kliche, W., Wiesmuller, L. and Reinstein, J. (1996). „Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5′-adenosyl) P5-(5′-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 Å: implications for water-mediated specificity”. Biochemistry. 35: 9716—9727. PMID 8703943.
- ^ Zhou, L., Lacroute, F. and Thornburg, R. (1998). „Cloning, expression in Escherichia coli, and characterization of Arabidopsis thaliana UMP/CMP kinase”. Plant Physiol. 117: 245—254. PMID 9576794.
- ^ Van Rompay, A.R., Johansson, M. and Karlsson, A. (1999). „Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme”. Mol. Pharmacol. 56: 562—569. PMID 10462544.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- UMP/CMP+kinase на US National Library of Medicine Medical Subject Headings (MeSH)