Жучна со сулфотрансфераза
žučna so sulfotransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.8.2.14 | ||||||||
CAS broj | 65802-92-8 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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žučna so sulfotransferaza (EC 2.8.2.14, BAST I, žučna kiselina:3'-fosfoadenozin-5'-fosfosulfat sulfotransferaza, žučna so:3'fosfoadenozin-5'-fosfosulfat:sulfotransferaza, žučno kiselinska sulfotransferaza I, glikolithoholatna sulfotransferaza) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:glikolitoholat sulfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 3'-fosfoadenilil sulfat + glikolithoholat adenozin 3',5'-bisfosfat + glikolithoholat 3-sulfat
- (2) 3'-fosfoadenilil sulfat + taurolithoholat adenozin 3',5'-bisfosfat + taurolithoholat sulfat
Formiranje sulfat estara žučne kiseline je esencijalni korak u prevenciji toksičnosti monohidroksi žučne kiseline kod mnogih vrsta.
Reference[уреди | уреди извор]
- ^ Chen, L.-J., Bolt, R.J. and Admirand, W.H. (1977). „Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts”. Biochim. Biophys. Acta. 480: 219—227. PMID 831833.
- ^ Barnes, S., Waldrop, R., Crenshaw, J., King, R.J. and Taylor, K.B. (1986). „Evidence for an ordered reaction mechanism for bile salt: 3′phosphoadenosine-5′-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate”. J. Lipid Res. 27: 1111—1123. PMID 3470420.
- ^ Barnes, S., Buchina, E.S., King, R.J., McBurnett, T. and Taylor, K.B. (1989). „Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties”. J. Lipid Res. 30: 529—540. PMID 2754334.
- ^ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137—174. PMID 12543708.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Bile-salt+sulfotransferase на US National Library of Medicine Medical Subject Headings (MeSH)