(-)-Бета-пиненска синтаза
| (-)-Beta-pinenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.120 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(-)-Beta-pinenska sintaza (EC 4.2.3.120, beta-geraniolenska sintaza, (-)-(1S,5S)-pinen sintaza, geranildifosfat difosfatna lijaza (formira pinen)) je enzim sa sistematskim imenom geranil-difosfat difosfat-lijaza (ciklizacija, formira (-)-beta-pinen).[1][2][3][4][5][6][7][8][9][10][11][12] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranil difosfat (-)-beta-pinen + difosfat
Ciklaza II iz Salvia officinalis formira jednake količine (-)-alfa-pinena, (-)-beta-pinena i (-)-kamfena.
Reference[уреди | уреди извор]
- ^ Croteau, R.B.; Wheeler, C.J.; Cane, D.E.; Ebert, R.; Ha, H.J. (1987). „Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (-)-α-pinene and (-)-β-pinene are synthesized by the same monoterpene cyclase via deprotonation of a common intermediate”. Biochemistry. 26: 5383—5389. PMID 3314988.
- ^ Croteau, R. & Satterwhite, D.M. (1989). „Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage”. J. Biol. Chem. 264: 15309—15315. PMID 2768265.
- ^ Croteau, R.; Satterwhite, D.M.; Cane, D.E.; Chang, C.C. (1988). „Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene”. J. Biol. Chem. 263: 10063—10071. PMID 3392006.
- ^ Pyun, H.J.; Wagschal, K.C.; Jung, D.I.; Coates, R.M.; Croteau, R. (1994). „Stereochemistry of the proton elimination in the formation of (+)- and (-)-α-pinene by monoterpene cyclases from sage (Salvia officinalis)”. Arch. Biochem. Biophys. 308: 488—496. PMID 8109979.
- ^ Lu, S.; Xu, R.; Jia, J.W.; Pang, J.; Matsuda, S.P.; Chen, X.Y. (2002). „Cloning and functional characterization of a β-pinene synthase from Artemisia annua that shows a circadian pattern of expression”. Plant Physiol. 130: 477—486. PMID 12226526.
- ^ Gijzen, M.; Lewinsohn, E.; Croteau, R. (1991). „Characterization of the constitutive and wound-inducible monoterpene cyclases of grand fir (Abies grandis)”. Arch. Biochem. Biophys. 289: 267—273. PMID 1898071.
- ^ Lewinsohn, E.; Gijzen, M.; Croteau, R. (1992). „Wound-inducible pinene cyclase from grand fir: purification, characterization, and renaturation after SDS-PAGE”. Arch. Biochem. Biophys. 293: 167—173. PMID 1731633.
- ^ Bohlmann, J.; Steele, C.L.; Croteau, R. (1997). „Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase”. J. Biol. Chem. 272: 21784—21792. PMID 9268308.
- ^ Hyatt, D.C. & Croteau, R. (2005). „Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of (-)-pinene synthase from Abies grandis”. Arch. Biochem. Biophys. 439: 222—233. PMID 15978541.
- ^ Savage, T.J.; Ichii, H.; Hume, S.D.; Little, D.B.; Croteau, R. (1995). „Monoterpene synthases from gymnosperms and angiosperms: stereospecificity and inactivation by cysteinyl- and arginyl-directed modifying reagents”. Arch. Biochem. Biophys. 320: 257—265. PMID 7625832.
- ^ Phillips, M.A.; Savage, T.J.; Croteau, R. (1999). „Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers”. Arch. Biochem. Biophys. 372: 197—204. PMID 10562434.
- ^ McKay, S.A.; Hunter, W.L.; Godard, K.A.; Wang, S.X.; Martin, D.M.v; Bohlmann, J.; Plant, A.L. (2003). „Insect attack and wounding induce traumatic resin duct development and gene expression of (-)-pinene synthase in Sitka spruce”. Plant Physiol. 133: 368—378. PMID 12970502.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- (-)-beta-pinene+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
