4-Хидрокси-4-метил-2-оксоглутаратна алдолаза
| 4-Hidroksi-4-metil-2-oksoglutaratna aldolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.3.17 | ||||||||
| CAS broj | 37290-65-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
4-Hidroksi-4-metil-2-oksoglutaratna aldolaza (EC 4.1.3.17, piruvatna aldolaza, gama-metil-gama-hidroksi-alfa-ketoglutarinska aldolaza, 4-hidroksi-4-metil-2-ketoglutaratna aldolaza, 4-hidroksi-4-metil-2-oksoglutaratna piruvat-lijaza, HMG aldolaza, CHA aldolaza, 4-karboksi-4-hidroksi-2-oksoadipatna aldolaza) je enzim sa sistematskim imenom 4-hidroksi-4-metil-2-oksoglutarat piruvat-lijaza (formira piruvat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 4-hidroksi-4-metil-2-oksoglutarat 2 piruvat
- (2) 2-hidroksi-4-oksobutan-1,2,4-trikarboksilat oksaloacetat + piruvat
Za dejstvo ovog enzima je neophodan divalentni metalni jon.
Reference[уреди | уреди извор]
- ^ Tack, B.F., Chapman, P.J. and Dagley, S. (1972). „Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase”. J. Biol. Chem. 247: 6444—6449. PMID 5076765.
- ^ Wood, W.A. (1972). „2-Keto-3-deoxy-6-phosphogluconic and related aldolases”. Ур.: Boyer, P.D. The Enzymes. 7 (3rd изд.). New York: Academic Press. стр. 281—302.
- ^ Maruyama, K. (1983). „Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase”. J. Biochem. (Tokyo). 93: 557—565. PMID 6841353.
- ^ Nogales, J., Canales, A., Jimenez-Barbero, J., Serra, B., Pingarron, J.M., Garcia, J.L. and Diaz, E. (2011). „Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida”. Mol. Microbiol. 79: 359—374. PMID 21219457.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Литература[уреди | уреди извор]
- Wood, W.A. (1972). „2-Keto-3-deoxy-6-phosphogluconic and related aldolases”. Ур.: Boyer, P.D. The Enzymes. 7 (3rd изд.). New York: Academic Press. стр. 281—302.
Spoljašnje veze[уреди | уреди извор]
- 4-hydroxy-4-methyl-2-oxoglutarate+aldolase на US National Library of Medicine Medical Subject Headings (MeSH)
