Бета-амиринска синтаза
| Beta-amirinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.39 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Beta-amirinska sintaza (EC 5.4.99.39, 2,3-oksidoskvalen beta-amirin ciklaza, AsbAS1, BPY, EtAS, GgbAS1, LjAMY1, MtAMY1, PNY, BgbAS) je enzim sa sistematskim imenom (3S)-2,3-epoksi-2,3-dihidroskvalen mutaza (ciklizacija, formira beta-amirin).[1][2][3][4][5][6][7][8][9][10][11] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (3S)-2,3-epoksi-2,3-dihidroskvalen beta-amirin
Neki organizmi poseduju monofunkcionalnu beta-amirinsku sintazu.
Reference[уреди | уреди извор]
- ^ Abe, I, Ebizuka, Y., Seo, S. and Sankawa, U. (1989). „Purification of squalene-2,3-epoxide cyclases from cell suspension cultures of Rabdosia japonica' Hara”. FEBS Lett. 249: 100—104.
- ^ Abe, I., Sankawa, U. and Ebizuka, Y. (1989). „Purification of 2,3-oxdosqualene:β-amyrin cyclase from pea seedlings”. Chem. Pharm. Bull. 37: 536—.
- ^ Kushiro, T., Shibuya, M. and Ebizuka, Y. (1998). „β-Amyrin synthase-cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants”. Eur. J. Biochem. 256: 238—244. PMID 9746369.
- ^ Hayashi, H., Huang, P., Kirakosyan, A., Inoue, K., Hiraoka, N., Ikeshiro, Y., Kushiro, T., Shibuya, M. and Ebizuka, Y. (2001). „Cloning and characterization of a cDNA encoding β-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice”. Biol. Pharm. Bull. 24: 912—916. PMID 11510484.
- ^ Husselstein-Muller, T., Schaller, H. and Benveniste, P. (2001). „Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana”. Plant Mol. Biol. 45: 75—92. PMID 11247608.
- ^ Iturbe-Ormaetxe, I., Haralampidis, K., Papadopoulou, K. and Osbourn, A.E. (2003). „Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus”. Plant Mol. Biol. 51: 731—743. PMID 12683345.
- ^ Zhang, H., Shibuya, M., Yokota, S. and Ebizuka, Y. (2003). „Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants”. Biol. Pharm. Bull. 26: 642—650. PMID 12736505.
- ^ Hayashi, H., Huang, P., Takada, S., Obinata, M., Inoue, K., Shibuya, M. and Ebizuka, Y. (2004). „Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra”. Biol. Pharm. Bull. 27: 1086—1092. PMID 15256745.
- ^ Kajikawa, M., Yamato, K.T., Fukuzawa, H., Sakai, Y., Uchida, H. and Ohyama, K. (2005). „Cloning and characterization of a cDNA encoding β-amyrin synthase from petroleum plant Euphorbia tirucalli L”. Phytochemistry. 66: 1759—1766. PMID 16005035.
- ^ Basyuni, M., Oku, H., Tsujimoto, E., Kinjo, K., Baba, S. and Takara, K. (2007). „Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae”. FEBS J. 274: 5028—5042. PMID 17803686.
- ^ Liu, Y., Cai, Y., Zhao, Z., Wang, J., Li, J., Xin, W., Xia, G. and Xiang, F. (2009). „Cloning and functional analysis of a β-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM”. Biol. Pharm. Bull. 32: 818—824. PMID 19420748.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Beta-amyrin+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
