Гермацрадиенолна синтаза
| Germacradienolna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.22 | ||||||||
| CAS broj | 211049-88-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Germacradienolna sintaza (EC 4.2.3.22, germakradienol/germakren-D sintaza, 2-trans,6-trans-farnezil-difosfat difosfat-lijaza (formira (1E,4S,5E,7R)-germakra-1(10),5-dien-11-ol)) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (1E,4S,5E,7R)-germakra-1(10),5-dien-11-ol).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat + H2O (1E,4S,5E,7R)-germakra-1(10),5-dien-11-ol + difosfat
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference[уреди | уреди извор]
- ^ Cane, D.E. & Watt, R.M. (2003). „Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis”. Proc. Natl. Acad. Sci. USA. 100: 1547—1551. PMID 12556563.
- ^ He, X. & Cane, D.E. (2004). „Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2)”. J. Am. Chem. Soc. 126: 2678—2679. PMID 14995166.
- ^ Gust, B., Challis, G.L., Fowler, K., Kieser, T. and Chater, K.F. (2003). „PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin”. Proc. Natl. Acad. Sci. USA. 100: 1541—1546. PMID 12563033.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Germacradienol+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
