ABT-670

ABT-670
IUPAC ime
	3-metil-N-(1-oksi-3',4',5',6'-tetrahidro-2'H-[2,4'-bipiridin]-1'-ilmetil)benzamid
Identifikatori
ATC kod	none
PubChem	CID 16094676
ChemSpider	17252978
ChEMBL	CHEMBL219182
Hemijski podaci
Formula	C19H23N3O2
Molarna masa	325,404 g/mol
	SMILES [O-][n+]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C; ;
	InChI InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23) ; Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N ;

ABT-670 je lek koji deluje kao potentan, oralno biodostupan dopaminski agonist koji je selektivan za D₄ podtip. On je razvijen kao mogući tretman za impotenciju,^[1] mada je njegova sadašnja primena ograničena na naučna istraživanja.^[2]

Vidi još

Reference

^ Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M (2006). „Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridine-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction”. Journal of Medicinal Chemistry. 49 (25): 7450—65. PMID 17149874. doi:10.1021/jm060662k.
^ Richards, Natalie; Wayman, Chris; Allers, Kelly A. (2009). „Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection”. Neuroscience Letters. 465 (3): 242—247. PMID 19733217. doi:10.1016/j.neulet.2009.08.078.

[1] Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M (2006). „Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridine-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction”. Journal of Medicinal Chemistry. 49 (25): 7450—65. PMID 17149874. doi:10.1021/jm060662k.

[2] Richards, Natalie; Wayman, Chris; Allers, Kelly A. (2009). „Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection”. Neuroscience Letters. 465 (3): 242—247. PMID 19733217. doi:10.1016/j.neulet.2009.08.078.

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