Adrenorfin
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| Nazivi | |
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| IUPAC naziv
L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-N~5~-(diaminomethylidene)-L-ornithyl-N~5~-(diaminomethylidene)-D-ornithyl-L-valinamide
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| Identifikacija | |
3D model (Jmol)
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| ChemSpider | |
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| Svojstva | |
| C44H69N15O9S | |
| Molarna masa | 984,18 g/mol |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je   ?)
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| Reference infokutije | |
Adrenorfin (metorfamid) je endogeni, C-terminalno amidisani, opioidni oktapeptid (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2). On nastaje proteolitičim presecanjem proenkefalina A. Adrenorfin je široko rasprostranjen u mozgu sisara.[3][4][5][6][7]
Dobio je ime po činjenici da je originalno nađen u humanom feohromocitomnom tumoru izvedenom iz srži nadbubrežne žlezde. Naknadno je utvrđeno da je isto tako prisutan u normalnoj humanoj i goveđoj adrenalnoj meduli.[3] Adrenorfin ima potentno opioidno dejstvo. On deluje kao balansirani agonist μ- i κ-opioidnog receptora, a nema efekta na δ-opioidne receptore.[4] On ispoljava analgetičke i respiratorno depresantske efekte.[8]
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Literatura[uredi | uredi izvor]
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ а б Matsuo H, Miyata A, Mizuno K (1983). „Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour”. Nature. 305 (5936): 721—3. PMID 6633641.
- ^ а б E, Weber; Esch FS; Böhlen P (1983). „Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain”. Proceedings of the National Academy of Sciences of the United States of America. 80 (23): 7362—6. PMC 390055
. PMID 6316361.
- ^ Sonders M, Barchas JD, Weber E (1984). „Regional distribution of metorphamide in rat and guinea pig brain”. Biochemical and Biophysical Research Communications. 122 (3): 892—8. PMID 6477570. doi:10.1016/0006-291X(84)91174-4.
- ^ Miyata A, Mizuno K, Minamino N, Matsuo H (1984). „Regional distribution of adrenorphin in rat brain: comparative study with PH-8P”. Biochemical and Biophysical Research Communications. 120 (3): 1030—6. PMID 6732783. doi:10.1016/S0006-291X(84)80210-7.
- ^ Miyata A, Mizuno K, Honzawa M, Tohyama M, Matsuo H (1985). „Adrenorphin immunoreactivity in rat brain”. Neuropeptides. 5 (4-6): 517—20. PMID 2860609.
- ^ SF, Xu; Lu WX; Zhou KR (1985). „The analgesic and respiratory depressant actions of metorphamide in mice and rabbits”. Neuropeptides. 6 (2): 121—31. PMID 4000426.
