Dihidrofolatna sintaza
| Dihidrofolatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.12 | ||||||||
| CAS broj | 37318-62-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Dihidrofolatna sintaza (EC 6.3.2.12, dihidrofolatna sintetaza, 7,8-dihidrofolatna sintetaza, H2-folatna sintetaza, 7,8-dihidropteroat:L-glutamatna ligaza (ADP), dihidrofolatna sintetaza-folilpoliglutamatna sintetaza, folilpoli-(gama-glutamat) sintetaza-dihidrofolat sintaza, FHFS, FHFS/FPGS, dihidropteroat:L-glutamat ligaza (formira ADP), DHFS) je enzim sa sistematskim imenom 7,8-dihidropteroat:L-glutamat ligaza (formira ADP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
U pojedinim bakterijama, isti protein katalizuje reakcije ovog enzima i enzima EC 6.3.2.17.
Reference[uredi | uredi izvor]
- ^ Griffin, M.J. & Brown, G.M. (1964). „The biosynthesis of folic acid. III. Enzymatic formation of dihydrofolic acid from dihydropteroic acid and of tetrahydropteroylpolyglutamic acid compounds from tetrahydrofolic acid”. J. Biol. Chem. 239: 310—316. PMID 14114858.
- ^ Bognar, A.L., Osborne, C., Shane, B., Singer, S.C. and Ferone, R. (1985). „Folylpoly-γ-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product”. J. Biol. Chem. 260: 5625—5630. PMID 2985605.
- ^ Ravanel, S., Cherest, H., Jabrin, S., Grunwald, D., Surdin-Kerjan, Y., Douce, R. and Rébeillé, F. (2001). „Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana”. Proc. Natl. Acad. Sci. USA. 98: 15360—15365. PMID 11752472.
- ^ Cherest, H., Thomas, D. and Surdin-Kerjan, Y. (2000). „Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae”. J. Biol. Chem. 275: 14056—14063. PMID 10799479.
- ^ Cossins, E.A. & Chen, L. (1997). „Folates and one-carbon metabolism in plants and fungi”. Phytochemistry. 45: 437—452. PMID 9190084.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[uredi | uredi izvor]
- Dihydrofolate+synthase na US National Library of Medicine Medical Subject Headings (MeSH)
