L-765,314

L-765,314
IUPAC ime
	benzil (2S)-4-(4-amino-6,7-dimetoksihinazolin-2-il)-2-(tert-butilkarbamoil)piperazin-1-karboksilat
Identifikatori
ATC kod	none
PubChem	CID 6603904
IUPHAR/BPS	506
ChEMBL	CHEMBL19476
Hemijski podaci
Formula	C27H34N6O5
Molarna masa	522,595 g/mol
	SMILES COc3cc2c(cc3OC)nc(nc2N)N(CC1C(=O)NC(C)(C)C)CCN1C(=O)OCc4ccccc4; ;

L-765,314 je lek koji deluje kao potentan i selektivan antagonist za alfa-1 adrenergički receptor α_1B.^[1] On se uglavnom koristi za istraživanje uloge α_1B receptora u regulaciji krvnog pritiska,^[2]^[3] mada se smatra da α_1B receptor isto tako ima važnu ulogu u mozgu.^[4]

Reference[uredi | uredi izvor]

^ Patane MA, Scott AL, Broten TP, Chang RS, Ransom RW, DiSalvo J, Forray C, Bock MG (1998). „4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist ”. Journal of Medicinal Chemistry. 41 (8): 1205—8. PMID 9548811. doi:10.1021/jm980053f.
^ Yang XP, Chiba S (2002). „Effects of L-765,314, a selective and potent alpha 1B-adrenoceptor antagonist, on periarterial nerve electrical stimulation-induced double-peaked constrictor responses in isolated dog splenic arteries”. Japanese Journal of Pharmacology. 89 (4): 429—32. PMID 12233824. doi:10.1254/jjp.89.429.
^ Görnemann T, Villalón CM, Centurión D, Pertz HH (2009). „Phenylephrine contracts porcine pulmonary veins via alpha(1B)-, alpha(1D)-, and alpha(2)-adrenoceptors”. European Journal of Pharmacology. 613 (1–3): 86—92. PMID 19376108. doi:10.1016/j.ejphar.2009.04.011.
^ Hillman KL, Doze VA, Porter JE (2007). „Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus”. The Journal of Pharmacology and Experimental Therapeutics. 321 (3): 1062—8. PMID 17337632. doi:10.1124/jpet.106.119297.

Spoljašnje veze[uredi | uredi izvor]

[pmid9548811-1] Patane MA, Scott AL, Broten TP, Chang RS, Ransom RW, DiSalvo J, Forray C, Bock MG (1998). „4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist ”. Journal of Medicinal Chemistry. 41 (8): 1205—8. PMID 9548811. doi:10.1021/jm980053f.

[pmid12233824-2] Yang XP, Chiba S (2002). „Effects of L-765,314, a selective and potent alpha 1B-adrenoceptor antagonist, on periarterial nerve electrical stimulation-induced double-peaked constrictor responses in isolated dog splenic arteries”. Japanese Journal of Pharmacology. 89 (4): 429—32. PMID 12233824. doi:10.1254/jjp.89.429.

[pmid19376108-3] Görnemann T, Villalón CM, Centurión D, Pertz HH (2009). „Phenylephrine contracts porcine pulmonary veins via alpha(1B)-, alpha(1D)-, and alpha(2)-adrenoceptors”. European Journal of Pharmacology. 613 (1–3): 86—92. PMID 19376108. doi:10.1016/j.ejphar.2009.04.011.

[pmid17337632-4] Hillman KL, Doze VA, Porter JE (2007). „Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus”. The Journal of Pharmacology and Experimental Therapeutics. 321 (3): 1062—8. PMID 17337632. doi:10.1124/jpet.106.119297.

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