RAD51

S Vikipedije, slobodne enciklopedije
RAD51 homolog (S. cerevisiae)
Rad51 filament baziran na 1SZP​.[1]
Dostupne strukture
1B22​, 1N0W​
Identifikatori
Simboli RAD51; BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RECA
Vanjski ID OMIM: 179617 MGI: 97890 HomoloGene: 2155 GeneCards: RAD51 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5888 19361
Ensembl ENSG00000051180 ENSMUSG00000027323
UniProt Q06609 Q08297
RefSeq (mRNA) NM_001164269.1 NM_011234.4
RefSeq (protein) NP_001157741.1 NP_035364.1
Lokacija (UCSC) Chr 15:
40.99 - 41.02 Mb		 Chr 2:
118.94 - 118.97 Mb
PubMed pretraga [1] [2]

RAD51 je eukariotski gen. Protein kodiran ovim genom je član RAD51 proteinske familije koja pomaže u popravci dvolančanih prekida DNK. Članovi RAD51 familije su homologni sa bakterijkim RecA i kvaščanim Rad51. Ovaj protein je visoko konzerviran kod većine eukariota, od kvasca do ljudi.

Varijante[uredi | uredi izvor]

Dve alternativno splajsovane transkriptne varijante ovog gena, koje kodiraju zasebne proteina, su poznate. Transkriptne varijante koje koriste alternativne polyA signale postoje.

Interakcije[uredi | uredi izvor]

RAD51 možed da formira interakcije sa BRE,[2] RAD54B,[3] Serinska proteinska kinaza ATM,[4] BRCC3,[2] BARD1,[2] BRCA2,[2][5][6][7][8][9][10][11][12][13][14][15][16] UBE2I,[17][18] Abl gen,[4] BRCA1,[2][15][19][20] ATRX,[3][21] RAD52,[4] DMC1,[22] P53[2][23][24] i Protein Blumovog sindroma.[25]

Reference[uredi | uredi izvor]

  1. ^ Conway AB, Lynch TW, Zhang Y, Fortin GS, Fung CW, Symington LS, Rice PA (2004). „Crystal structure of a Rad51 filament”. Nat Struct Mol Biol. 11 (8): 791—6. PMID 15235592. 
  2. ^ а б в г д ђ Dong, Yuanshu; Hakimi Mohamed-Ali; et al. (2003). „Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair”. Mol. Cell. United States. 12 (5): 1087—99. ISSN 1097-2765. PMID 14636569. doi:10.1016/S1097-2765(03)00424-6. 
  3. ^ а б Tanaka, K; Hiramoto T; et al. (2000). „A novel human rad54 homologue, Rad54B, associates with Rad51”. J. Biol. Chem. UNITED STATES. 275 (34): 26316—21. ISSN 0021-9258. PMID 10851248. doi:10.1074/jbc.M910306199. 
  4. ^ а б в Chen, G; Yuan S S; et al. (1999). „Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl”. J. Biol. Chem. UNITED STATES. 274 (18): 12748—52. ISSN 0021-9258. PMID 10212258. doi:10.1074/jbc.274.18.12748. 
  5. ^ Sharan, S K; Morimatsu M; et al. (1997). „Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2”. Nature. ENGLAND. 386 (6627): 804—10. ISSN 0028-0836. PMID 9126738. doi:10.1038/386804a0. 
  6. ^ Lin, Horng-Ru; Ting Nicholas S Y; et al. (2003). „M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex”. J. Biol. Chem. United States. 278 (38): 35979—87. ISSN 0021-9258. PMID 12815053. doi:10.1074/jbc.M210659200. 
  7. ^ Yu, David S; Sonoda Eiichiro; et al. (2003). „Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2”. Mol. Cell. United States. 12 (4): 1029—41. ISSN 1097-2765. PMID 14580352. doi:10.1016/S1097-2765(03)00394-0. 
  8. ^ Chen, P L; Chen C F; et al. (1998). „The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 95 (9): 5287—92. ISSN 0027-8424. PMC 20253 Слободан приступ. PMID 9560268. doi:10.1073/pnas.95.9.5287. 
  9. ^ Sarkisian, C J; Master S R; et al. (2001). „Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals”. J. Biol. Chem. United States. 276 (40): 37640—8. ISSN 0021-9258. PMID 11477095. doi:10.1074/jbc.M106281200. 
  10. ^ Wong, A K; Pero R; et al. (1997). „RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2”. J. Biol. Chem. UNITED STATES. 272 (51): 31941—4. ISSN 0021-9258. PMID 9405383. doi:10.1074/jbc.272.51.31941. 
  11. ^ Katagiri, T; Saito H; et al. (1998). „Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51”. Genes Chromosomes Cancer. UNITED STATES. 21 (3): 217—22. ISSN 1045-2257. PMID 9523196. doi:10.1002/(SICI)1098-2264(199803)21:3<217::AID-GCC5>3.0.CO;2-2. 
  12. ^ Pellegrini, Luca; Yu David S; et al. (2002). „Insights into DNA recombination from the structure of a RAD51-BRCA2 complex”. Nature. England. 420 (6913): 287—93. ISSN 0028-0836. PMID 12442171. doi:10.1038/nature01230. 
  13. ^ Tarsounas, Madalena; Davies Adelina A; et al. (2004). „RAD51 localization and activation following DNA damage”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. England. 359 (1441): 87—93. ISSN 0962-8436. PMC 1693300 Слободан приступ. PMID 15065660. doi:10.1098/rstb.2003.1368. 
  14. ^ Liu, J; Yuan Y; et al. (2001). „Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2”. Oncogene. England. 20 (3): 336—45. ISSN 0950-9232. PMID 11313963. doi:10.1038/sj.onc.1204098. 
  15. ^ а б Chen, J; Silver D P; et al. (1998). „Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells”. Mol. Cell. UNITED STATES. 2 (3): 317—28. ISSN 1097-2765. PMID 9774970. doi:10.1016/S1097-2765(00)80276-2. 
  16. ^ Marmorstein, L Y; Ouchi T; Aaronson S A (1998). „The BRCA2 gene product functionally interacts with p53 and RAD51”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 95 (23): 13869—74. ISSN 0027-8424. PMC 24938 Слободан приступ. PMID 9811893. doi:10.1073/pnas.95.23.13869. 
  17. ^ Kovalenko, O V; Plug A W; et al. (1996). „Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (7): 2958—63. ISSN 0027-8424. PMC 39742 Слободан приступ. PMID 8610150. doi:10.1073/pnas.93.7.2958. 
  18. ^ Shen, Z; Pardington-Purtymun P E; et al. (1996). „Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system”. Genomics. UNITED STATES. 37 (2): 183—6. ISSN 0888-7543. PMID 8921390. doi:10.1006/geno.1996.0540. 
  19. ^ Scully, R; Chen J; et al. (1997). „Association of BRCA1 with Rad51 in mitotic and meiotic cells”. Cell. UNITED STATES. 88 (2): 265—75. ISSN 0092-8674. PMID 9008167. doi:10.1016/S0092-8674(00)81847-4. 
  20. ^ Wang, Q; Zhang H; et al. (2001). „Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1”. Oncogene. England. 20 (34): 4640—9. ISSN 0950-9232. PMID 11498787. doi:10.1038/sj.onc.1204625. 
  21. ^ Sigurdsson, Stefan; Van Komen Stephen; et al. (2002). „Homologous DNA pairing by human recombination factors Rad51 and Rad54”. J. Biol. Chem. United States. 277 (45): 42790—4. ISSN 0021-9258. PMID 12205100. doi:10.1074/jbc.M208004200. 
  22. ^ Masson, J Y; Davies A A; et al. (1999). „The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51”. EMBO J. ENGLAND. 18 (22): 6552—60. ISSN 0261-4189. PMC 1171718 Слободан приступ. PMID 10562567. doi:10.1093/emboj/18.22.6552. 
  23. ^ Stürzbecher, H W; Donzelmann B; et al. (1996). „p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction”. EMBO J. ENGLAND. 15 (8): 1992—2002. ISSN 0261-4189. PMC 450118 Слободан приступ. PMID 8617246. 
  24. ^ Buchhop, S; Gibson M K; et al. (1997). „Interaction of p53 with the human Rad51 protein”. Nucleic Acids Res. ENGLAND. 25 (19): 3868—74. ISSN 0305-1048. PMC 146972 Слободан приступ. PMID 9380510. doi:10.1093/nar/25.19.3868. 
  25. ^ Wu, L; Davies S L; et al. (2001). „Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51”. J. Biol. Chem. United States. 276 (22): 19375—81. ISSN 0021-9258. PMID 11278509. doi:10.1074/jbc.M009471200. 

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