Tipifarnib
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Identifikatori | |
| ATC kod | none |
| PubChem | CID 148193 |
| UNII | MAT637500A  |
| ChEMBL | CHEMBL289228 |
| Hemijski podaci | |
| Formula | C27H22Cl2N4O |
| Molarna masa | 489,396 |
| |
| |
Tipifarnib je organsko jedinjenje, koje sadrži 27 atoma ugljenika i ima molekulsku masu od 489,396 Da.
Osobine[uredi | uredi izvor]
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 3 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 4 |
| Particioni koeficijent[1] (ALogP) | 4,8 |
| Rastvorljivost[2] (logS, log(mol/L)) | -9,1 |
| Polarna površina[3] (PSA, Å2) | 64,2 |
Reference[uredi | uredi izvor]
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. Tekst „noedit” ignorisan (pomoć)
- ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. Tekst „noedit” ignorisan (pomoć)
Literatura[uredi | uredi izvor]
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. izd.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6. izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
