Amobarbital

Amobarbital
IUPAC ime
	5-etil-5-(3-metilbutil)-1,3-diazinan-2,4,6-trion
Klinički podaci
Drugs.com	Monografija
Identifikatori
CAS broj	57-43-2
ATC kod	N05CA02 (WHO)
PubChem	CID 2164
DrugBank	DB01351
ChemSpider	2079
KEGG	C07536
ChEMBL	CHEMBL2673
Hemijski podaci
Formula	C11H18N2O3
Molarna masa	226.2722
	SMILES CCC1(CCC(C)C)C(=O)NC(=O)NC1=O; ;
	InChI InChI=1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16) ; Key:VIROVYVQCGLCII-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	157 °C (315 °F)

Amobarbital je barbiturat sa hipnotičkim i sedativnim svojstvima. On se ne primenjuje se u lečenju anksioznosti. Njegove nuspojave su uglavnom posledica dozno zavisne CNS depresije i povišen rizik od zavisnosti pri dugotrajnoj upotrebi.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

Reference[уреди | уреди извор]

^ From Martindale, The Extra Pharmacopoeia, 30th ed, p.565
^ Kim HS, Wan X, Mathers DA, Puil E: Selective GABA-receptor actions of amobarbital on thalamic neurons. Br J Pharmacol. 2004 Oct;143(4):485-94. Epub 2004 Sep 20. PMID 15381635
^ Maynert EW: The alcoholic metabolites of pentobarbital and amobarbital in man. J Pharmacol Exp Ther. 1965 Oct;150(1):118-21. PMID 5855308
^ Tang BK, Kalow W, Grey AA: Amobarbital metabolism in man: N-glucoside formation. Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):45-53. PMID 684279
^ Soine PJ, Soine WH: High-performance liquid chromatographic determination of the diastereomers of 1-(beta-D-glucopyranosyl)amobarbital in urine. J Chromatogr. 1987 Nov 27;422:309-14. PMID 3437019
^ McCall WV: The addition of intravenous caffeine during an amobarbital interview. J Psychiatry Neurosci. 1992 Nov;17(5):195-7. PMID 1489761
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

Spoljašnje veze[уреди | уреди извор]

Amobarbital

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] From Martindale, The Extra Pharmacopoeia, 30th ed, p.565

[2] Kim HS, Wan X, Mathers DA, Puil E: Selective GABA-receptor actions of amobarbital on thalamic neurons. Br J Pharmacol. 2004 Oct;143(4):485-94. Epub 2004 Sep 20. PMID 15381635

[3] Maynert EW: The alcoholic metabolites of pentobarbital and amobarbital in man. J Pharmacol Exp Ther. 1965 Oct;150(1):118-21. PMID 5855308

[4] Tang BK, Kalow W, Grey AA: Amobarbital metabolism in man: N-glucoside formation. Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):45-53. PMID 684279

[5] Soine PJ, Soine WH: High-performance liquid chromatographic determination of the diastereomers of 1-(beta-D-glucopyranosyl)amobarbital in urine. J Chromatogr. 1987 Nov 27;422:309-14. PMID 3437019

[6] McCall WV: The addition of intravenous caffeine during an amobarbital interview. J Psychiatry Neurosci. 1992 Nov;17(5):195-7. PMID 1489761

[7] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.

[8] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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