Horizmatna sintaza
| Horizmatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.2.3.5 | ||||||||
| CAS broj | 9077-07-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Horizmatna sintaza (EC 4.2.3.5, 5-O-(1-karboksivinil)-3-fosfošikimat fosfat-lijaza) je enzim sa sistematskim imenom 5-O-(1-karboksivinil)-3-fosfošikimat fosfat-lijaza (formira horizmat).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za dejstvo ovog enzima je neophodan FMN.
Reference[уреди | уреди извор]
- ^ Gaertner, F.H. & Cole, K.W. (1973). „Properties of chorismate synthase in Neurospora crassa”. J. Biol. Chem. 248: 4602—4609. PMID 4146266.
- ^ Morell, H., Clark, M.J., Knowles, P.F. and Sprinson, D.B. (1967). „The enzymic synthesis of chorismic and prephenic acids from 3-enolpyruvylshikimic acid 5-phosphate”. J. Biol. Chem. 242: 82—90. PMID 4289188.
- ^ Welch, G.R., Cole, K.W. and Gaertner, F.H. (1974). „Chorismate synthase of Neurospora crassa: a flavoprotein”. Arch. Biochem. Biophys. 165: 505—518. PMID 4155270.
- ^ Bornemann, S., Lowe, D.J. and Thorneley, R.N. (1996). „The transient kinetics of Escherichia coli chorismate synthase: substrate consumption, product formation, phosphate dissociation, and characterization of a flavin intermediate”. Biochemistry. 35: 9907—9916. PMID 8703965.
- ^ Bornemann, S., Theoclitou, M.E., Brune, M., Webb, M.R., Thorneley, R.N. and Abell, C. (2000). „A secondary β deuterium kinetic isotope effect in the chorismate synthase reaction”. Bioorg. Chem. 28: 191—204. PMID 11034781.
- ^ Osborne, A., Thorneley, R.N., Abell, C. and Bornemann, S. (2000). „Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthase reaction”. J. Biol. Chem. 275: 35825—35830. PMID 10956653.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Chorismate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
