Leukotrien-A4 hidrolaza
| Leukotrien-A4 hidrolaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.3.2.6 | ||||||||
| CAS broj | 90119-07-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Leukotrien-A4 hidrolaza (EC 3.3.2.6, LTA4 hidrolaza, LTA4H, leukotrienska A4 hidrolaza) je enzim sa sistematskim imenom (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoksiikosa-7,9,11,14-tetraenoatna hidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- leukotrien A4 + H2O leukotrien B4
Ova bifunkcionalna cinkova metaloproteaza deluje kao epoksidna hidrolaza i aminopeptidaza.
Reference[уреди | уреди извор]
- ^ Evans, J.F., Dupuis, P. and Ford-Hutchinson, A.W. (1985). „Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils”. Biochim. Biophys. Acta. 840: 43—50. PMID 3995081.
- ^ Minami, M., Ohno, S., Kawasaki, H., Rådmark, O., Samuelsson, B., Jörnvall, H., Shimizu, T., Seyama, Y. and Suzuki, K. (1987). „Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase - complete primary structure of an enzyme involved in eicosanoid synthesis”. J. Biol. Chem. 262: 13873—13876. PMID 3654641.
- ^ Haeggström, J., Meijer, J. and Rådmark, O. (1986). „Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase”. J. Biol. Chem. 261: 6332—6337. PMID 3009453.
- ^ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1—51. PMID 15748653.
- ^ Fretland, A.J. & Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41—59. PMID 11154734.
- ^ Orning, L., Gierse, J.K. and Fitzpatrick, F.A. (1994). „The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity”. J. Biol. Chem. 269: 11269—11267. PMID 8157657.
- ^ Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). „Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers”. J. Biol. Chem. 262: 10200—10205. PMID 3038871.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Leukotriene-A4+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
