Lijaza fotoprodukta spora
| Spore photoproduct lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.99.14 | ||||||||
| CAS broj | 37290-70-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Lijaza fotoprodukta spora (EC 4.1.99.14, SAM, SP lijaza, SPL, SplB, SplG) je enzim koji popravlja posebnu vrstu oštećenja formiranih UV ozračenjem bakterijske DNK. Ovaj mehanizam popravke je jedan od razloga za otpornot pojedinih bakterijskih spora. Ovaj enzim je zavistan od radikala SAM. Putem serije reakcija radikala fotodimer, 3 5-timinil-5,6-dihidrotimin, se razlaže u dva funkcionalna prstena timina.[1][2]
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Reference[уреди | уреди извор]
- ^ Susan C. Wang & Perry A. Frey (2007). „S-adenosylmethionine as an oxidant: the radical SAM superfamily”. Trends in Biochemical Sciences. 32 (3): 101. PMID 17291766. doi:10.1016/j.tibs.2007.01.002.Note that the SPL drawings are incorrect in this paper and the erratum
- ^ Jeffrey M. Buis; Jennifer Cheek; Efthalia Kalliri & Joan B. Broderick (2006). „Characterization of an Active Spore Photoproduct Lyase, a DNA Repair Enzyme in the Radical S-Adenosylmethionine Superfamily”. Journal of Biological Chemistry. 281 (36): 25994—26003. PMID 16829680. doi:10.1074/jbc.M603931200.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
