Lubiproston

Lubiproston
Klinički podaci
Drugs.com	Monografija
Farmakokinetički podaci
Poluvreme eliminacije	0,9 - 1,4 h
Izlučivanje	Renalno
Identifikatori
CAS broj	136790-76-6
ATC kod	A06AX03 (WHO)
PubChem	CID 656719
DrugBank	DB01046
ChemSpider	571057
KEGG	C13707
ChEMBL	CHEMBL1201134
Hemijski podaci
Formula	C20H32F2O5
Molarna masa	390,462
	SMILES [H][C@@]12CC(=O)[C@@H](CCCCCCC(O)=O)[C@@]1([H])CC[C@@](O)(O2)C(F)(F)CCCC; ;
	InChI InChI=1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15+,17+,20+/m0/s1 ; Key:WGFOBBZOWHGYQH-DKYLXPRQSA-N ;

Lubiproston je organsko jedinjenje, koje sadrži 20 atoma ugljenika i ima molekulsku masu od 390,462 Da.^[1]^[2]^[3]^[4]^[3]^[5]^[6]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	5
Broj donora vodonika	2
Broj rotacionih veza	11
Particioni koeficijent^[7] (ALogP)	3,8
Rastvorljivost^[8] (logS, log(mol/L))	-4,3
Polarna površina^[9] (PSA, Å²)	83,8

Reference

^ Crowell MD, Harris LA, DiBaise JK, Olden KW. „Activation of type-2 chloride channels: a novel therapeutic target for the treatment of chronic constipation”. Curr Opin Investig Drugs. 8 (1): 66—70. 2007 Jan. PMID 17263187. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Lacy BE, Chey WD. „Lubiprostone: chronic constipation and irritable bowel syndrome with constipation”. Expert Opin Pharmacother. 10 (1): 143—52. 2009 Jan. PMID 19236188. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ ^а ^б Ambizas EM, Ginzburg R: Lubiprostone: a chloride channel activator for treatment of chronic constipation. Ann Pharmacother. . 41 (6). 2007 Jun: 957—64. PMID 17519292. Проверите вредност парамет(а)ра за датум: |date= (помоћ); Недостаје или је празан параметар |title= (помоћ). Epub 2007 May 22.
^ Lacy BE, Levy LC: Lubiprostone: a novel treatment for chronic constipation. Clin Interv Aging. 2008;. 3 (2): 357—64. PMID 18686757. Недостаје или је празан параметар |title= (помоћ)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Lubiprostone

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Crowell MD, Harris LA, DiBaise JK, Olden KW. „Activation of type-2 chloride channels: a novel therapeutic target for the treatment of chronic constipation”. Curr Opin Investig Drugs. 8 (1): 66—70. 2007 Jan. PMID 17263187. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Lacy BE, Chey WD. „Lubiprostone: chronic constipation and irritable bowel syndrome with constipation”. Expert Opin Pharmacother. 10 (1): 143—52. 2009 Jan. PMID 19236188. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[#1-3] а ^б Ambizas EM, Ginzburg R: Lubiprostone: a chloride channel activator for treatment of chronic constipation. Ann Pharmacother. . 41 (6). 2007 Jun: 957—64. PMID 17519292. Проверите вредност парамет(а)ра за датум: |date= (помоћ); Недостаје или је празан параметар |title= (помоћ). Epub 2007 May 22.

[4] Lacy BE, Levy LC: Lubiprostone: a novel treatment for chronic constipation. Clin Interv Aging. 2008;. 3 (2): 357—64. PMID 18686757. Недостаје или је празан параметар |title= (помоћ)

[5] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[6] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[7] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[8] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[9] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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